期刊论文

中文

特产研究

1001-4721

2024

46

01

24-30+36

10.16720/j.cnki.tcyj.2024.010

21C0883:湖南省教育厅科学研究项目 :湖南中医药大学十四五生物工程重点学科项目

本校为第一机构

为探索不同浓度的裸燕麦水提取物对阿尔茨海默病（Alzheimer’s disease,AD）小鼠的影响和作用机制。本文采用腹腔注射氯化铝构建AD模型,建模后对50只AD模型小鼠随机分为AD组、多奈哌齐组、裸燕麦水提取物低、中、高剂量组（85%、45%、15%）（N=10）,另设空白对照组进行生理盐水灌胃（N=10）,所有小鼠连续灌胃给药28 d。干预结束后通过Y迷宫和新物体识别法检测小鼠学习和记忆能力,HE染色法观察小鼠海马组织病理变化,免疫组织化学染色法检测小鼠脑组织中p-Tau、Aβ和GFAP表达水平,采用ELISA法检测IL-1β、TNF-α、SOD、GST和MDA表达水平。Y迷宫和新物体识别结果显示,高浓度裸燕麦水提取物能明显提...

To explore the effects and mechanism of hulless oat extract in different concentrations on Alzheimer's disease(AD)mice.AD model was established by intraperitoneal injection of aluminum chloride.After modeling,50 model mice were randomly divided into AD,Donepezil,the water extract of hulless oats lower,middle,and high dose groups(85％,45％,15％)(N=10).Another blank control group was given normal saline intragastric administration(N=1 0).And continuous intragastric administrated for 28 days.The learning and memory abilities of mice were tested by...