PM2.5 (aerodynamicale quivalent diameter, Dp≤2.5 μm) is the main component of atmospheric particulates. A large number of researches suggest that PM2.5 could affect cardiovascular system directly or indirectly, while oxidative stress reaction and inflammation reaction are the main pathogenic mechanisms. The research progress of PM2.5 on pyroptosis and the damage of endothelial cell by related pathways of oxidative stress and inflammation reaction, and its prevention and treat-ment with traditional Chinese medicine were reviewed. All results...