Exposure to MoS2 nanosheets or bulk activated Kruppel-like factor 4 in 3D Caco-2 spheroids in vitro and mouse intestines in vivo

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成果类型：

期刊论文

作者：

Xiao, You;He, Yuanyuan;Xu, Chongsi;Li, Mei;Hu, Fan;...

通讯作者：

Zhenquan Wang

作者机构：

[Hu, Fan; Li, Mei; Wang, Wei; Xu, Chongsi; Xiao, You] Hunan Univ Tradit Chinese Med, Affiliated Hosp 2, Dept Anorectal 5, Changsha, Peoples R China.

[He, Yuanyuan] Hunan Univ, Hunan Univ Chinese Med, Grad Sch, Changsha, Peoples R China.

[Wang, Zhenquan] Hunan Univ Tradit Chinese Med, Affiliated Hosp 2, Dept Anorectal 3, Changsha 410005, Peoples R China.

[Cao, Yi] Univ South China, Hengyang Med Sch, Sch Publ Hlth, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang, Peoples R China.

通讯机构：

[Zhenquan Wang] T

Third Department of Anorectal, The Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha, China

语种：

英文

关键词：

3D Caco-2 spheroids;Kruppel-like factor 4 (KLF4);MoS2 nanosheets (NSs);Oral exposure;RNA-sequencing

期刊：

ENVIRONMENTAL TOXICOLOGY

ISSN：

1520-4081

年：

2023

卷：

期：

页码：

1925-1938

DOI：

10.1002/tox.23819

基金类别：

This study was financially supported by Natural Science Foundation of Hunan Province (2021JJ40413), Hunan Educational Department (20B449) and Double First‐class projects of Hunan University of Chinese Medicine (2021ZYX18).

机构署名：

本校为第一机构

院系归属：

第二中医临床医学院

研究生院

摘要：

MoS(2) nanosheets (NSs) are novel 2D nanomaterials (NMs) being used in many important fields. Recently, we proposed the need to evaluate the influences of NMs on Kruppel-like factors (KLFs) even if these materials are relatively biocompatible. In this study, we investigated the influences of MoS(2) NSs or bulk on KLF4 signaling pathway in 3D Caco-2 spheroids in vitro and mouse intestines in vivo. Through the analysis of our previous RNA-sequencing data, we found that exposure to MoS(2) NSs or bulk activated KLF4 expression in 3D Caco-2 spheroid...

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Exposure to MoS2 nanosheets or bulk activated Kruppel-like factor 4 in 3D Caco-2 spheroids in vitro and mouse intestines in vivo

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