期刊论文

中文

中国生物化学与分子生物学报

1007-7626

2023

39

4

516-523

10.13865/j.cnki.cjbmb.2023.03.1609

No.82003931:国家自然科学基金 No.2021M690974:中国博士后科学基金面上项目 No.20B445:湖南省教育厅优秀青年基金资助项目 No.2021RC3100:湖湘青年科技创新人才资助项目

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核糖核酸酶A(RNase A)是一种广泛应用于酶学、生物化学、结构生物学等领域研究的工具酶,能特异性水解RNA的胞嘧啶(C)或尿嘧啶(U)残基,能有效杀伤肿瘤细胞及抑制HIV-1病毒复制。研究表明,RNase A家族成员...展开更多 核糖核酸酶A(RNase A)是一种广泛应用于酶学、生物化学、结构生物学等领域研究的工具酶,能特异性水解RNA的胞嘧啶(C)或尿嘧啶(U)残基,能有效杀伤肿瘤细胞及抑制HIV-1病毒复制。研究表明,RNase A家族成员参与细胞增殖、存活、发育和分化,迁移和入侵等多种生理和病理过程;人体内RNase A活性和蛋白质表达水平与胰腺癌、卵巢癌、膀胱癌和甲状腺癌等肿瘤发病密切相关。准确监测RNase A水...

The RNase A family members are involved in various physiological and pathological processes such as cell proliferation,survival,development,differentiation,migration,and invasion.Because the RNase A activity and protein expression levels in humans are closely related to...MORE The RNase A family members are involved in various physiological and pathological processes such as cell proliferation,survival,development,differentiation,migration,and invasion.Because the RNase A activity and protein expression levels in humans are closely related to the development of pancreatic,ovarian,bladder,and t...