期刊论文

Xia, Bo-hou

英文

Journal of Pharmaceutical and Biomedical Analysis

0731-7085

2022

209

4

114532

10.1016/j.jpba.2021.114532

National Key Research and Development Program of China [2017YFC1701900]; Excellent youth project of Hunan Provincial Department of Education [19B416]; Science and Technology Project of Changsha [kq2004054]; Special Funds for Guiding Local Scientific and Technological Development by the Central Government [2019XF5076]; First-class Discipline Project on Chinese Pharmacology of Hunan University of Chinese Medicine [201803]

本校为第一且通讯机构

Metabolomics is applied to explore the curative effect of complex systems, such as Chinese medicine. Intrauterine adhesion (IUA) harms the reproductive system and affects fertility, and hence is a significant public health concern. Prunella vulgaris oil (PVO) protects the reproductive system and exerts anti-inflammatory effects, but its effect on IUA and the underlying mechanism is unclear. In this study, we established a serum metabolomics method based on GC-TOF-MS to evaluate the mechanism of PVO in the IUA rat model established by mechanical injury and infection. Animal experiments showed t...