期刊论文

Advances in research of hyaluronic acid modified nanomicelles for targeting tumor therapy and drug release behavior

Luo, L.

中文

中国药科大学学报

1000-5048

2019

50

6

641-647

10.11665/j.issn.1000-5048.20190602

No.81774362:国家自然科学基金 No.81303004:国家自然科学基金 No.201852:大学生创新项目

本校为第一机构

透明质酸(HA)是一种具有良好生物相容性、生物可降解性的天然线性多糖,通过细胞表面分化簇44(CD44)受体靶向肿瘤。其作为抗肿瘤药物传递载体广泛应用于肿瘤治疗领域,已成为肿瘤靶向给药系统研究的热点。CD44是透明质酸高亲和性的受体,因其在肿瘤细胞过表达,可以作为肿瘤标志物或靶向受体。许多肿瘤都表现出CD44受体的过度表达,如乳腺癌、结肠直肠癌、肝癌和胰腺癌等。CD44配体通过与纳米药物载体结合,可以提高纳米载体对肿瘤细胞的亲和力。HA结构中因含有CD44配体具备有效的肿瘤靶向效应而闻名,通过HA-CD44受体介导的内吞作用途径可以增强肿瘤细胞的摄取。本文对HA纳米胶束在临床肿瘤治疗中的进...

Hyaluronic acid, also called hyaluronan (HA) is a biocompatible and biodegradable linear polysaccharide which is of interest for tumor targeting through cell surface CD44 receptors. It is widely applied in the field of tumor therapy as an anticancer drug delivery carrier, and has become a hot spot in the research of tumor targeted drug delivery system. In tumor drug therapy, the key to reduce toxicity is to actively target tumors by using anatomical, pathophysiological and microenvironmental differences between malignant tumors and normal tissu...