Alprostadil (prostaglandin E1, PGE1) has many pharmacological actions, such as vasodila- tion, anti-inflammatory, anti- platelet aggregation, protection of vascular endothelial ceils, prevention of athe- rosclerosis, and so on. As the development of its formulations lipid carrier (Lipo-PGE1), alprostadil has been used more widely in clinic. Pharmacological mechanism of alprostadil and its application status in pulmonary hypertension, bronchial asthma, bronchiolitis and chr...