期刊论文

Mechanism of Yiyi Fuzi Baijiang powder in treatment of hepatocellular carcinoma on network pharmacology

中文

中国新药与临床杂志

1007-7669

2021

40

05

384-389

10.14109/j.cnki.xyylc.2021.05.13

国家自然科学基金（81873303）； 湖南省自然基金青年项目（2016JJ6113）； 湖南中医药大学中医学一流学科开放基金（2018ZYX51）； 湖南省卫健委科研计划项目（20200949）；

本校为其他机构

目的通过网络药理学方法探讨薏苡附子败酱散治疗肝细胞癌的作用机制。方法运用中药系统药理学数据库和分析平台（TCMSP）获取薏苡仁、附子、败酱草的活性成分和作用靶点,从GeneCards数据库中获取肝细胞癌候选靶点,并筛选出中药与疾病的交集靶点;采用STRING数据库构建蛋白-蛋白相互作用（PPI）网络,g:Profiler数据分析平台进行GO富集和KEGG通路富集分析。通过Cytoscape 3.7.2软件构建疾病-活性成分-关键靶点-通路网络并进行拓扑结构分析。结果最终筛选获得薏苡附子败酱散活性成分43个,205个潜在靶点,肝细胞癌候选靶点6 330个,两者交集关键靶点172个。通过评估口服药物生物利用度和类药性的大小筛...

AIM To explore the mechanism of Yiyi Fuzi Baijiang powder in the treatment of hepatocellular carcinoma by network pharmacology. METHODS The active components and targets of coix seed, prepared commonot and dahurian patrinia herb were obtained from the Chinese Medicine System Pharmacology Database and Analysis Platform(TCMSP), the candidate targets of hepatocellular carcinoma were obtained from GeneCards database, and the intersection targets of traditional Chinese medicine and disease were screened. The protein-protein interaction(PPI) network ...