期刊论文

Li, Ling

英文

Neuroscience

0306-4522

2018

373

1

207-217

10.1016/j.neuroscience.2018.01.026

National Institute on Aging of the National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [AG056976, AG056025]; College of Pharmacy of the University of Minnesota; Academic Health Center of the University of MinnesotaUniversity of Minnesota System; NIH pre-doctoral training fellowship [AG029796]; Bighley/Rowell Graduate fellowship from the College of Pharmacy at the University of Minnesota; NATIONAL INSTITUTE ON AGINGUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [T32AG029796, T32AG029796, T32AG029796, T32AG029796, R21AG056025, T32AG029796, R21AG056025, T32AG029796, RF1AG056976, T32AG029796, T32AG029796, T32AG029796, T32AG029796, T32AG029796, T32AG029796] Funding Source: NIH RePORTER

本校为其他机构

Isoprenoids and prenylated proteins regulate a variety of cellular functions, including neurite growth and synaptic plasticity. Importantly, they are implicated in the pathogenesis of several diseases, including Alzheimer's disease (AD). Recently, we have shown that two protein prenyltransferases, farnesyltransferase (FT) and geranylgeranyltransferase-1 (GGT), have differential effects in a mouse model of AD. Haplodeficiency of either FT or GGT attenuates amyloid-beta deposition and neuroinflammation but only reduction in FT rescues cognitive function. The current study aimed to elucidate the ...