Nanofiber-reinforced decellularized amniotic membrane improves limbal stem cell transplantation in a rabbit model of corneal epithelial defect

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhou, Zhengbing;Long, Da;Hsu, Chih-Chien;Liu, Huanhuan;Chen, Long;...

通讯作者：

Tuffaha, Sami;Mao, Hai-Quan

作者机构：

[Tang, Juyu; Zhou, Zhengbing] Cent S Univ, Xiangya Hosp, Dept Hand & Microsurg, Changsha 410008, Hunan, Peoples R China.

[Li, Xiaowei; Mao, Hai-Quan; Liu, Huanhuan; Chen, Long; Zhou, Zhengbing] Johns Hopkins Univ, Sch Med, Translat Tissue Engn Ctr, Baltimore, MD 21287 USA.

[Li, Xiaowei; Mao, Hai-Quan; Chen, Long; Zhou, Zhengbing] Johns Hopkins Univ, Inst NanoBioTechnol, Baltimore, MD 21218 USA.

[Long, Da] Hunan Univ Chinese Tradit Med, Hosp 1, Dept Ophthalmol, Changsha 410007, Hunan, Peoples R China.

[Yiu, Samuel; Hsu, Chih-Chien; Long, Da] Johns Hopkins Univ, Sch Med, Wilmer Eye Inst, Baltimore, MD 21287 USA.

通讯机构：

[Tuffaha, Sami] 7

[Mao, Hai-Quan] 3

720 Rutland Ave,Russ 749D, Baltimore, MD 21205 USA.

3400 N Charles St,Croft Hall 100, Baltimore, MD 21218 USA.

语种：

英文

关键词：

Amniotic membrane;Composite membrane;Electrospinning;Limbal stem cell deficiency;Nanofibers;Transplantation

期刊：

Acta Biomaterialia

ISSN：

1742-7061

年：

2019

卷：

页码：

310-320

DOI：

10.1016/j.actbio.2019.08.027

基金类别：

This work was partially supported by Johns Hopkins University School of Engineering and a grant from Wuhan Kangchuang Technology Co. Ltd. to Johns Hopkins University.

机构署名：

本校为其他机构

摘要：

Human amniotic membrane (AM) offers unique advantages as a matrix to support the transplantation of limbal stem cells (LSCs) due to its inherent pro-regenerative and anti-inflammatory properties. However, the widespread use of AM in clinical treatments of ocular surface disorders is limited by its weak mechanical strength and fast degradation, and high cost associated with preserving freshly isolated AM. Here we constructed a composite membrane consisting of an electrospun bioabsorbable poly(ε-caprolactone) (PCL) nanofiber mesh to significantl...

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Nanofiber-reinforced decellularized amniotic membrane improves limbal stem cell transplantation in a rabbit model of corneal epithelial defect

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