Rhein Inhibited Ferroptosis and EMT to Attenuate Diabetic Nephropathy by Regulating the Rac1/NOX1/beta-Catenin Axis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xiong, Dan;Hu, Wei;Han, Xiaofang;Cai, Yahong

通讯作者：

Hu, W

作者机构：

[Xiong, Dan] Hunan Univ Chinese Med, Hosp 1, Dept Nephrol, Changsha 410021, Hunan, Peoples R China.

[Hu, W; Hu, Wei] Hunan Univ Chinese Med, Hosp 1, Dept Endocrinol, Changsha 410021, Hunan, Peoples R China.

[Han, Xiaofang] Lanzhou Univ, Hosp 1, Dept Infect Dis, Lanzhou 730099, Gansu, Peoples R China.

[Cai, Yahong] Hunan Univ Chinese Med, Hosp 1, Dept Chron Dis Management, Changsha 410021, Hunan, Peoples R China.

通讯机构：

[Hu, W ] H

Hunan Univ Chinese Med, Hosp 1, Dept Endocrinol, Changsha 410021, Hunan, Peoples R China.

语种：

英文

关键词：

DN;EMT;Rac1/NOX1/β-catenin axis;ferroptosis;rhein

期刊：

Frontiers in Bioscience-Landmark

ISSN：

2768-6701

年：

2023

卷：

期：

页码：

100

DOI：

10.31083/j.fbl2805100

基金类别：

Natural Science Founda-tion of Hunan Province [2020JJ5439]; Hunan Clinical Medical Technology Innovation and Guidance Project [2021SK51418]; Key Nursing Project of Hunan University of Traditional Chinese Medicine [2019XJJJ072]; Chinese Medicine Inheritance And Innovation Project of Back-bone Talents of Western Medicine learn Traditional Chinese Medicine [08-01-03]

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

摘要：

Background: Diabetic nephropathy (DN) is one of the most serious complications of diabetes. Rhein has been reported to be effective in treating DN. This study aimed to investigate the role and mechanism of rhein in the treatment of DN. Methods: High glucose-induced (HG) podocyte injury model and streptozocin-induced (STZ) DN mouse model were constructed and intervened with rhein. Cell viability was detected by Cell Counting Kit-8 (CCK-8) assay. The reactive oxygen species (ROS) level was measured by flow cytometry. The expression of Ras-related C3 botulinum toxin substrate 1 (Rac1), NADPH Oxid...

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Rhein Inhibited Ferroptosis and EMT to Attenuate Diabetic Nephropathy by Regulating the Rac1/NOX1/beta-Catenin Axis

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