Ezetimibe suppresses cholesterol accumulation in lipid-loaded vascular smooth muscle cells in vitro via MAPK signaling

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成果类型：

期刊论文

作者：

Qin, Li;Yang, Yun-bo;Yang, Yi-xin;Zhu, Neng;Gong, Yong-zhen;...

通讯作者：

Liao, Duan-fang

作者机构：

[Yang, Yun-bo; Liao, Duan-fang; Li, Shun-xiang; Gong, Yong-zhen; Qin, Li] Hunan Univ Chinese Med, Sch Pharm, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.

[Zhang, Cai-ping; Qin, Li] South China Univ, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Yang, Yun-bo; Yang, Yi-xin] Univ Western Ontario, London Hlth Sci Ctr, Matthew Mailing Ctr Translat Transplantat Studies, London, ON N6A 5A5, Canada.

[Yang, Yun-bo; Zhu, Neng] Cent S Univ, Xiang Ya Hosp 2, Changsha 410011, Hunan, Peoples R China.

[Zhu, Neng] South China Univ, Affiliated Hosp 2, Hengyang 421001, Peoples R China.

通讯机构：

[Liao, Duan-fang] H

Hunan Univ Chinese Med, Sch Pharm, Div Stem Cell Regulat & Applicat, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

atherosclerosis;vascular smooth muscle cells;cholesterol;ezetimibe;caveolin-1;SREBP-1;MAPK

关键词(中文)：

血管平滑肌细胞;MAPK信号通路;胆固醇水平;体外;信号抑制;WESTERN印迹;高效液相色谱法

期刊：

中国药理学报

ISSN：

1671-4083

年：

2014

卷：

期：

页码：

1129-1136

DOI：

10.1038/aps.2014.10

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81000946, 81270359, 81173047, 12JJ5068]; Construct Program of the Pharmaceutical Science Key Discipline in Hunan province

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

Aim: To investigate the mechanisms of anti-atherosclerotic action of ezetimibe in rat vascular smooth muscle cells (VSMCs) in vitro. Methods: VSMCs of SD rats were cultured in the presence of Chol:MβCD (10 μg/mL) for 72 h, and intracellular lipid droplets and cholesterol levels were evaluated using Oil Red O staining, HPLC and Enzymatic Fluorescence Assay, respectively. The expression of caveolin-1，sterol response element-binding protein-1 (SREBP-1) and ERK1/2 were analyzed using Western blot assays. Translocation of SREBP-1 and ERK1/2 was d...

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Ezetimibe suppresses cholesterol accumulation in lipid-loaded vascular smooth muscle cells in vitro via MAPK signaling

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