Ursodeoxycholic acid protects interstitial Cajal-like cells in the gallbladder from undergoing apoptosis by inhibiting TNF-α expression

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成果类型：

期刊论文

作者：

Wan, Jiang-fan;Chu, Shi-feng;Zhou, Xin;Li, Yue-ting;He, Wen-bin;...

通讯作者：

Chen, Nai-hong

作者机构：

[Tan, Feng; Wan, Jiang-fan; Chen, Nai-hong; Wang, Qi] Guangzhou Univ Chinese Med, Inst Clin Pharmacol, Guangzhou 510080, Guangdong, Peoples R China.

[Ai, Qi-di; Wan, Jiang-fan; Chen, Nai-hong; He, Wen-bin; Zhou, Xin; Chu, Shi-feng; Luo, Piao] Chinese Acad Med Sci, Inst Materia Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.

[Ai, Qi-di; Wan, Jiang-fan; Chen, Nai-hong; He, Wen-bin; Zhou, Xin; Chu, Shi-feng; Luo, Piao] Chinese Acad Med Sci, Neurosci Ctr, Beijing 100050, Peoples R China.

[Ai, Qi-di; Wan, Jiang-fan; Chen, Nai-hong; He, Wen-bin; Zhou, Xin; Chu, Shi-feng; Luo, Piao] Peking Union Med Coll, Beijing 100050, Peoples R China.

[Li, Yue-ting] Beijing Hosp Integrated Tradit & Western Med, Beijing 100039, Peoples R China.

通讯机构：

[Chen, Nai-hong] G

[Chen, Nai-hong] C

[Chen, Nai-hong] P

[Chen, Nai-hong] H

Guangzhou Univ Chinese Med, Inst Clin Pharmacol, Guangzhou 510080, Guangdong, Peoples R China.

语种：

英文

关键词：

ursodeoxycholic acid;gallstones;interstitial Cajal-like cells

关键词(中文)：

胆囊炎;房间;空隙;保护;伤害;胆石

期刊：

中国药理学报

ISSN：

1671-4083

年：

2018

卷：

期：

页码：

1493-1500

DOI：

10.1038/aps.2017.206

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81473570, U1402221, 81560663, 81560685]; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study [BZ0150]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-1-004]; Scientific Research Foundation of the Higher Education Institutions of Hunan Province [15K091]; State Key Laboratory Fund Open Project [GTZK201610]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2013M540066]

机构署名：

本校为通讯机构

院系归属：

药学院

摘要：

Hypomotility is a common symptom of gallstone disease, which is accompanied by a loss of interstitial Cajal-like cells (ICLCs) in the gallbladder. Ursodeoxycholic acid (UDCA) is widely used in treating gallstone disease, and has shown anti-apoptotic and anti-inflammatory effects apart from its ability to dissolve gallstones. In this study, we investigated the anti-apoptotic and anti-inflammatory effects of UDCA on ICLCs in guinea pigs with gallstones. Guinea pigs were fed a high-cholesterol diet for 8 weeks to induce the formation of gallstones...

摘要(中文)：

运动不足是胆石疾病的普通症状，它被空隙的象 Cajal 一样房间(ICLC ) 的损失在胆囊伴随。Ursodeoxycholic 酸(UDCA ) 广泛地在治疗胆石疾病被使用，并且除了它溶解胆石的能力显示出 anti-apoptotic 和反煽动性的效果。在这研究，我们与胆石在畿尼猪在 ICLC 上调查了 anti-apoptotic 和 UDCA 的反煽动性的效果。畿尼猪被喂为 8 个星期到的一本高胆固醇的食谱导致胆石的形成。一组动物被管理 UDCA (在跟随 553 的 consultation.ResultsA 总数的临床的管理的一个变化请教的 50 mgith 为 268 个婴儿被执行(gestational 年龄：在到控制的 CP 和 RAP.ResultsCompared 之间的 27ffect QOL 预言者(51.0...

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Ursodeoxycholic acid protects interstitial Cajal-like cells in the gallbladder from undergoing apoptosis by inhibiting TNF-α expression

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