CZ-7, a new derivative of Claulansine F, ameliorates 2VO-induced vascular dementia in rats through a Nrf2-mediated antioxidant responses

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成果类型：

期刊论文

作者：

Liu, Dan-dan;Yuan, Xia;Chu, Shi-feng;Chen, Chen;Ren, Qian;...

通讯作者：

Chen, Nai-hong

作者机构：

[Zang, Ying-da; Chen, Nai-hong; Wang, Sha-sha; Chen, Chen; Ren, Qian; Zhang, Dong-ming; Liu, Dan-dan; Chu, Shi-feng] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.

[Zang, Ying-da; Chen, Nai-hong; Wang, Sha-sha; Chen, Chen; Ren, Qian; Zhang, Dong-ming; Liu, Dan-dan; Chu, Shi-feng] Chinese Acad Med Sci, Neurosci Ctr, Beijing 100050, Peoples R China.

[Zang, Ying-da; Chen, Nai-hong; Wang, Sha-sha; Chen, Chen; Ren, Qian; Zhang, Dong-ming; Liu, Dan-dan; Chu, Shi-feng] Peking Union Med Coll, Beijing 100050, Peoples R China.

[Yuan, Xia] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.

[Chen, Nai-hong; Luo, Piao; Zhu, Tian-bi; Ai, Qi-di; Lin, Mei-yu] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Chen, Nai-hong] C

[Chen, Nai-hong] P

[Chen, Nai-hong] H

Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.

Chinese Acad Med Sci, Neurosci Ctr, Beijing 100050, Peoples R China.

语种：

英文

关键词：

claulansine F;CZ-7;vascular dementia;2VO rats;chronic cerebral hypoperfusion;spatial memory;oxidative stress;Nrf2;HO-1;NQO1

期刊：

中国药理学报

ISSN：

1671-4083

年：

2019

卷：

期：

页码：

425-440

DOI：

10.1038/s41401-018-0078-7

基金类别：

National Natural Science Foundation of China (Nos. 81730096, 81730093, U1402221, 81603316, 81560685) the CAMS Innovation Fund for Medical Sciences (No. CIFMS)(No. 2016-I2M-1-004) the State Key Laboratory Fund Open Project (No. GTZK201610) the China Postdoctoral Science Foundation (No. 2013M540066) the PUMC Graduate Education and Teaching Reform Project (No. 10023201600801) the Scientific Research Foundation of the Higher Education Institutions of Hunan Province (No. 15K091) the Project of NDRC and State Administration of Traditional Chinese Medicine (No. 60011000) the Hunan Provincial Key Laboratory for Standardization of Important Chinese Herbal Pieces (No. BG201701, 4981-0901020).

机构署名：

本校为通讯机构

摘要：

Vascular dementia (VD) results from accumulated damage in the vascular system, which is characterized by progressive impairments in memory and cognition and is second only to Alzheimer’s disease (AD) in prevalence among all types of dementia. In contrast to AD, there is no FDA-approved treatment for VD owing to its multiple etiologies. In this study, we investigated whether CZ-7, a new derivative of Claulansine F (Clau F) with verified neuroprotective activity in vitro, could ameliorate the cognitive impairment of rats with permanent occlusion...

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CZ-7, a new derivative of Claulansine F, ameliorates 2VO-induced vascular dementia in rats through a Nrf2-mediated antioxidant responses

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