期刊论文

Qin, L

英文

中国药理学报

1671-4083

2021

42

9

1472-1485

10.1038/s41401-020-00572-6

This work was supported by grants from the National Natural Science Foundation of China (No. 81973668, No. 81774130 and No. 81270359); the Natural Science Foundation of Hunan Province for Distinguished Young Scholars (No. 2018JJ1018); and the First-Class Discipline of Pharmaceutical Science of Hunan.

本校为第一且通讯机构

Celastrol is a triterpene derived from the traditional Chinese medicine Tripterygium wilfordii Hook f, which displays potential anticancer activity. In the present study, we investigated the anticancer effects of celastrol against clear cell renal cell carcinoma (ccRCC) and the underlying mechanisms. Using Cancer Genome Atlas (TCGA) database and genotype-tissue expression (GTEx) database we conducted a bioinformatics analysis, which showed that the mRNA levels of liver-X receptors α (LXRα) and ATP-binding cassette transporter A1 (ABCA1) in cc...