Celastrol induces lipophagy via the LXRα/ABCAl pathway in clear cell renal cell carcinoma

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成果类型：

期刊论文

作者：

Zhang, Chan-juan;Zhu, Neng;Long, Jia;Wu, Hong-tao;Wang, Yu-xiang;...

通讯作者：

Qin, Li

作者机构：

[Liao, Duan-fang; Zhang, Chan-juan; Wang, Yu-xiang; Long, Jia; Qin, Li] Hunan Univ Chinese Med, Sch Pharm, Div Stem Cell Regulat & Applicat, Changsha 410208, Peoples R China.

[Zhu, Neng] Hunan Univ Chinese Med, Hosp 1, Dept Urol, Changsha 410007, Peoples R China.

[Wu, Hong-tao] Cent South Univ, XiangYa Hosp 2, Dept Urol, Changsha 410011, Peoples R China.

[Liu, Bi-yuan] Hunan Univ Chinese Med, Sch Med, Dept Immunol, Changsha 410208, Peoples R China.

通讯机构：

[Qin, Li] H

Hunan Univ Chinese Med, Sch Pharm, Div Stem Cell Regulat & Applicat, Changsha 410208, Peoples R China.

语种：

英文

关键词：

ABCA1;LXRα;celastrol;clear cell renal cell carcinoma;epithelial-mesenchymal transition;lipophagy

期刊：

中国药理学报

ISSN：

1671-4083

年：

2021

卷：

期：

页码：

1472-1485

DOI：

10.1038/s41401-020-00572-6

基金类别：

This work was supported by grants from the National Natural Science Foundation of China (No. 81973668, No. 81774130 and No. 81270359); the Natural Science Foundation of Hunan Province for Distinguished Young Scholars (No. 2018JJ1018); and the First-Class Discipline of Pharmaceutical Science of Hunan.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

第一中医临床学院

药学院

摘要：

Celastrol is a triterpene derived from the traditional Chinese medicine Tripterygium wilfordii Hook f, which displays potential anticancer activity. In the present study, we investigated the anticancer effects of celastrol against clear cell renal cell carcinoma (ccRCC) and the underlying mechanisms. Using Cancer Genome Atlas (TCGA) database and genotype-tissue expression (GTEx) database we conducted a bioinformatics analysis, which showed that the mRNA levels of liver-X receptors α (LXRα) and ATP-binding cassette transporter A1 (ABCA1) in cc...

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Celastrol induces lipophagy via the LXRα/ABCAl pathway in clear cell renal cell carcinoma

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