Potential application of endocannabinoid system agents in neuropsychiatric and neurodegenerative diseases-focusing on FAAH/MAGL inhibitors

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ren, Si-yu;Wang, Zhen-zhen;Zhang, Yi;Chen, Nai-hong*

通讯作者：

Chen, Nai-hong

作者机构：

[Ren, Si-yu; Chen, Nai-hong] Hunan Univ Chinese Med, Changsha 410208, Peoples R China.

[Ren, Si-yu; Chen, Nai-hong] Hunan Engn Technol Ctr Standardizat & Funct Chine, Changsha 410208, Peoples R China.

[Wang, Zhen-zhen; Chen, Nai-hong] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.

[Wang, Zhen-zhen; Chen, Nai-hong] Chinese Acad Med Sci & Peking Union Med Coll, Neurosci Ctr, Beijing 100050, Peoples R China.

[Zhang, Yi] Beijing Univ Chinese Med, Sch Chinese Med, Dept Anat, Beijing 102488, Peoples R China.

通讯机构：

[Chen, Nai-hong] H

[Chen, Nai-hong] C

Hunan Univ Chinese Med, Changsha 410208, Peoples R China.

Hunan Engn Technol Ctr Standardizat & Funct Chine, Changsha 410208, Peoples R China.

Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.

语种：

英文

关键词：

Alzheimer's disease;Parkinson's disease;FAAH;MAGL;depression;anxiety

期刊：

中国药理学报

ISSN：

1671-4083

年：

2020

卷：

期：

页码：

1263-1271

DOI：

10.1038/s41401-020-0385-7

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81573636, 81773924]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7182114]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-1-004]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2018RC350010]; Project of NDRC; State Administration of Traditional Chinese Medicine [ZYBZH-Y-HUN-24]

机构署名：

本校为第一且通讯机构

摘要：

The endocannabinoid system (ECS) has received extensive attention for its neuroprotective effect on the brain. This system comprises endocannabinoids, endocannabinoid receptors, and the corresponding ligands and proteins. The molecular players involved in their regulation and metabolism are potential therapeutic targets for neuropsychiatric diseases including anxiety, depression and neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). The inhibitors of two endocannabinoid hydrolases, i.e., fatty acid amide...

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Potential application of endocannabinoid system agents in neuropsychiatric and neurodegenerative diseases-focusing on FAAH/MAGL inhibitors

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