Pyk2 inhibition attenuates hypoxic-ischemic brain injury in neonatal mice

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成果类型：

期刊论文

作者：

Zhu, Jie;Chu, Shi-feng;Peng, Ye;Liu, Dan-dan;Chen, Chen;...

通讯作者：

Zhang, Zhao;Chen, Nai-Hong

作者机构：

[Chen, Chen; Peng, Ye; Chen, Nai-hong; Jian, Wen-xuan; Chu, Shi-feng; Liu, Dan-dan; Zhang, Zhao; Zhu, Jie] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China.

[Chen, Chen; Peng, Ye; Chen, Nai-hong; Jian, Wen-xuan; Chu, Shi-feng; Liu, Dan-dan; Zhang, Zhao; Zhu, Jie] Chinese Acad Med Sci & Peking Union Med Coll, Neurosci Ctr, Beijing 100050, Peoples R China.

[Peng, Ye; Chen, Nai-hong] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Peoples R China.

[Chen, Nai-hong; Jian, Wen-xuan] Guangzhou Univ Chinese Med, Inst Clin Pharmacol, Guangzhou 510720, Peoples R China.

[Sun, Hong-shuo; Feng, Zhong-ping] Univ Toronto, Fac Med, Dept Physiol, Toronto, ON, Canada.

通讯机构：

[Zhang, Zhao; Chen, Nai-Hong] S

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China.

Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, 510720, China.

语种：

英文

关键词：

neonatal mice;hypoxic-ischemic brain injury;Pyk2;NMDA receptor;excitotoxicity;HIF-1α

期刊：

中国药理学报

ISSN：

1671-4083

年：

2022

卷：

期：

页码：

797-810

DOI：

10.1038/s41401-021-00694-5

基金类别：

This work was supported by the National Natural Science Foundation of China (81730096, 81873026, 81973499), the CAMS Innovation Fund for Medical Sciences (CIFMS) (2016-I2M-1-004), the Drug Innovation Major Project (2018ZX09711001-003-005, 2018ZX09711001-002-007), the Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study (BZ0150), the opening Program of Shanxi Key Laboratory of Chinese Medicine Encephalopathy (CME-OP-2017001), and the High-End Foreign Experts introduction program (G20200001485).

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Newborns suffering from hypoxia-ischemia (HI) brain injury still lack effective treatment. Proline-rich tyrosine kinase 2 (Pyk2) is a non-receptor tyrosine kinase, which is highly correlated with transient ischemic brain injury in adult. In this study, we investigated the role of Pyk2 in neonatal HI brain injury. HI was induced in postnatal day 7 mouse pups by unilateral common carotid artery ligation followed by hypoxic exposure. Pyk2 interference lentivirus (LV-Pyk2 shRNA) was constructed and injected into unilateral cerebral ventricle of neo...

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Pyk2 inhibition attenuates hypoxic-ischemic brain injury in neonatal mice

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