A multicenter single‐arm trial of neoadjuvant pyrotinib and trastuzumab plus chemotherapy for HER2‐positive breast cancer

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成果类型：

期刊论文

作者：

Qiyun Shi;Xiaowei Qi;Peng Tang;Linjun Fan;Li Chen;...

通讯作者：

Yi Zhang<&wdkj&>Jun Jiang<&wdkj&>Yi Zhang Yi Zhang Yi Zhang<&wdkj&>Jun Jiang Jun Jiang Jun Jiang

作者机构：

[Yi Sun; Yi Sun Yi Sun Yi Sun] Department of Breast and Thyroid Surgery, Xuchang Central Hospital, Xuchang, Henan, China

[Jinhui Hu; Jinhui Hu Jinhui Hu Jinhui Hu] Department of Breast Surgery, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China

[Yanwu Zhang; Yanwu Zhang Yanwu Zhang Yanwu Zhang] Department of Breast Surgery, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

[Xiaowei Qi; Peng Tang; Linjun Fan; Li Chen; Shushu Wang; Yan Liang; Ying Hu; Minghao Wang; Lin Ren; Guozhi Zhang; Xuanni Tan; Long Yuan; Junze Du; Xiujuan Wu; Yi Zhang; Jun Jiang; Xiaowei Qi Xiaowei Qi Xiaowei Qi; Peng Tang Peng Tang Peng Tang; Linjun Fan Linjun Fan Linjun Fan; Li Chen Li Chen Li Chen; Shushu Wang Shushu Wang Shushu Wang; Yan Liang Yan Liang Yan Liang; Ying Hu Ying Hu Ying Hu; Minghao Wang Minghao Wang Minghao Wang; Lin Ren Lin Ren Lin Ren; Guozhi Zhang Guozhi Zhang Guozhi Zhang; Xuanni Tan Xuanni Tan Xuanni Tan; Long Yuan Long Yuan Long Yuan; Junze Du Junze Du Junze Du; Xiujuan Wu Xiujuan Wu Xiujuan Wu; Yi Zhang Yi Zhang Yi Zhang; Jun Jiang Jun Jiang Jun Jiang] Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China

The Eighth Medical Center of Chinese PLA General Hospital, Beijing, China

通讯机构：

[Yi Zhang; Jun Jiang; Yi Zhang Yi Zhang Yi Zhang; Jun Jiang Jun Jiang Jun Jiang] D

Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China

语种：

英文

关键词：

HER2‐positive breast cancer;multicenter study;neoadjuvant therapy;pyrotinib;trastuzumab

期刊：

MedComm

ISSN：

2688-2663

年：

2023

卷：

期：

页码：

e435-

DOI：

10.1002/mco2.435

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

In this multicenter, single‐arm trial, we investigated the efficacy and safety of the ECPy‐THPy regimen (epirubicin, cyclophosphamide, and pyrotinib followed by docetaxel, trastuzumab, and pyrotinib) as neoadjuvant therapy for patients with stage II–III HER2‐positive breast cancer. Our results revealed that tpCR was achieved in 107 (68.6%) out of 156 patients, which was in line with our previous pilot study and numerically higher than the tpCR rate in previous phase III KRISTINE trial and the phase III POENY trial. Abstract The objective of...

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A multicenter single‐arm trial of neoadjuvant pyrotinib and trastuzumab plus chemotherapy for HER2‐positive breast cancer

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