Quercetin attenuates cerebral ischemic injury by inhibiting ferroptosis via Nrf2/HO-1 signaling pathway

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成果类型：

期刊论文

作者：

Peng, Caiwang;Ai, Qidi;Zhao, Fengyan;Li, Hengli;Sun, Yang;...

通讯作者：

Yang, Yantao;Chen, Naihong;Liu, F;Chen, NH

作者机构：

[Ai, Qidi; Peng, Caiwang; Sun, Yang; Zhao, Fengyan; Tang, Keyan; Yang, Yantao; Chen, Naihong; Li, Hengli; Liu, Fang] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R China.

[Ai, Qidi; Peng, Caiwang; Sun, Yang; Yang, YT; Liu, Fang; Zhao, Fengyan; Chen, NH; Tang, Keyan; Yang, Yantao; Chen, Naihong; Li, Hengli] Ctr Standardizat & Funct Engn Tradit Chinese Med H, Changsha 410208, Peoples R China.

[Peng, Caiwang; Zhao, Fengyan; Tang, Keyan; Li, Hengli; Liu, Fang] Educ Dept Hunan Prov, Key Lab Modern Res TCM, Changsha 410208, Peoples R China.

[Chen, NH; Chen, Naihong] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing 100050, Peoples R China.

[Liu, Fang] Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Peoples R China.

通讯机构：

[Yang, YT; Liu, F ; Chen, NH ; Chen, NH] C

Ctr Standardizat & Funct Engn Tradit Chinese Med H, Changsha 410208, Peoples R China.

Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing 100050, Peoples R China.

Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Peoples R China.

语种：

英文

关键词：

Cerebral ischaemia;Ferroptosis;Nrf2/HO-1 signalling pathway;Quercetin

期刊：

European Journal of Pharmacology

ISSN：

0014-2999

年：

2024

卷：

963

页码：

176264

DOI：

10.1016/j.ejphar.2023.176264

基金类别：

National Natural Science Foundation of China [81704064, U2202214]; Natural Science Foundation of Hunan Province, China [2022JJ30436]; Natural Science Foundation of Changsha City, China [kq2202259]; Hunan University of Chinese Medicine discipline construction project; Key Discipline Project on Chinese Pharmacology of Hunan University of Chinese Medicine [202302]; A 2022 Hunan University of Traditional Chinese Medicine Graduate Innovation Project [2022CX91]

机构署名：

本校为第一机构

院系归属：

药学院

摘要：

AIMS: Ischemic stroke is a severe cerebrovascular disease in which neuronal death continually occurs through multiple forms, including apoptosis, autophagy, pyroptosis and ferroptosis. Quercetin (QRC), as a natural flavonoid compound, has been reported to have pharmacological effects on ischemic injury accompanied by unclear anti-ferroptotic mechanisms. This study is designed to investigate the therapeutic effects of QRC against ferroptosis in ischemic stroke. MATERIALS AND METHODS: In vivo, the model of MCAO rats were used to assess the protective effect of QRC on cerebral ischemic. Additiona...

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Quercetin attenuates cerebral ischemic injury by inhibiting ferroptosis via Nrf2/HO-1 signaling pathway

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