期刊论文

中文

中国中医眼科杂志

1002-4379

2010

20

6

319-322

10.13444/j.cnki.zgzyykzz.002733

湖南省科技厅项目资助（2008FJ3068）；

本校为第一机构

目的 探索目安眼膏抗单纯疱疹病毒(HSV-1)作用的最佳浓度,为目安眼膏处方设计提供依据.方法 将模型兔随机分为7组,每组4只(8眼),采用兔角膜上皮划痕法造模.Ⅰ组～Ⅳ组:分别给予含0%、3%、5%、7%蜂蜜和3%阿昔洛韦(ACV)的目安眼膏;Ⅴ组:模型组;Ⅵ组:给予3%N昔洛韦眼膏;VII组:凝胶基质组.接种病毒后第9天,透射电镜观察角膜上皮情况.结果 通过电镜观察,含5%蜂蜜的目安眼膏组用药后兔角膜上皮表面微绒毛丰富,细胞层次排列规则,可见相互重叠的扁圆形细胞核,核型较规则,细胞间连接紧密,细胞外胶原纤维结构排列整齐,基质中成纤维细胞形态正常.细胞结构、形态恢复均优于其它各组.结论 含5%蜂蜜的目安眼膏...

OBJECTIVE To explore the optimum concentration of the Muan Ointment against herpes simplex virus(HSV-1) so as to provide a basis for the prescription.METHODS Rabbits were molded in corneal epithelium scarification.Then the model rabbits were randomly divided into seven groups,each with four(8eyes).GroupⅠ to GroupⅣ contained respectively 0%,3%,5% and 7% of honey and 3% acyclovir(ACV)Muan Ointment;GroupⅤ:model group;GroupⅥ:3% acyclovir ointment;GroupⅦ:gel matrix group.Each eye was observed by transmission electron microscopy(TEM) on the nint...