Contribution of D4-F to ABCA1 Expression and Cholesterol Efflux in THP-1 Macrophage-derived Foam Cells

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成果类型：

期刊论文

作者：

Liu, Xie-Hong;Xiao, Ji;Mo, Zhong-Cheng;Yin, Kai;Jiang, Jin;...

通讯作者：

Tang, Chao-Ke

作者机构：

[Tan, Chun-Zhi; Tang, Chao-Ke; Liu, Xie-Hong; Yin, Kai; Tang, Ya-Ling; Mo, Zhong-Cheng; Jiang, Jin; Xiao, Ji; Cui, Li-Bao] Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Changsha, Hunan, Peoples R China.

[Liu, Xie-Hong] Changsha Med Univ, Changsha, Hunan, Peoples R China.

[Liao, Duan-Fang] Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.

[Tang, Chao-Ke] Univ S China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Peoples R China.

通讯机构：

[Tang, Chao-Ke] U

Univ S China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

ABCA1, D4-F, Cdc42/cAMP/PKA, atherosclerosis, reverse cholesterol transport

期刊：

Journal of Cardiovascular Pharmacology

ISSN：

0160-2446

年：

2010

卷：

期：

页码：

309-319

DOI：

10.1097/FJC.0b013e3181edaf69

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30470720]; Postdoctor Sciences Foundation of ChinaChina Postdoctoral Science Foundation [2005037157]; Hunan Provincial Natural Sciences Foundation of China [06jj5058]

机构署名：

本校为其他机构

摘要：

Adenosine triphosphate-binding cassette transporter A1 (ABCA1) plays a crucial role in apolipoprotein A-I (apoA-I) binding activity and promotes cellular cholesterol efflux. ApoA-I mimetic peptide D4-F has reported to have the similar ability as apoA-I. However, the detailed mechanisms of ABCA1 regulation by D4-F are not understood. In the present study, we investigated the effects of D4-F on ABCA1 expression and ABCA1-dependent cholesterol efflux and examined the role of Cdc42/cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) pathway on the regulation of ABCA1 by D4-F in THP-1 macr...

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Contribution of D4-F to ABCA1 Expression and Cholesterol Efflux in THP-1 Macrophage-derived Foam Cells

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