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Prediction and analysis of quality markers for Chuantieling gel patches based on HPLC fingerprinting and network pharmacology

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成果类型:
期刊论文
作者:
Du, Lixin;Lu, Huiling;Xiao, Yifei;Guo, Zhihua;Li, Ya
通讯作者:
Li, Y
作者机构:
[Lu, Huiling; Xiao, Yifei; Li, Ya; Du, Lixin] Hunan Univ Chinese Med, Coll Pharm, Changsha, Peoples R China.
[Guo, Zhihua] Hunan Univ Chinese Med, Coll Chinese Med, Changsha, Peoples R China.
[Li, Y; Li, Ya] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Peoples R China.
通讯机构:
[Li, Y ] H
Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Peoples R China.
语种:
英文
关键词:
Chuantieling gel patch;fingerprint;HPLC;network pharmacology;Q-markers
期刊:
Biomedical Chromatography
ISSN:
0269-3879
年:
2024
卷:
38
期:
2
页码:
e5773-
基金类别:
This research was funded by the Key Scientific Research Project of the Hunan Provincial Education Department (grant number 20A384) and the First-class Discipline Project on Chinese Pharmacology of Hunan University of Chinese Medicine (no. 201803).
机构署名:
本校为第一机构
院系归属:
药学院
摘要:
The Chuantieling gel patch (CGP), a traditional Chinese medicine compound, is an external treatment for asthma. It has shown remarkable effectiveness in alleviating asthma-related airway hyperresponsiveness and inflammation. Nevertheless, there is currently no information available regarding the analysis of quality markers for CGP, and there is a need for further improvement in quality control research. In this study, we developed an HPLC fingerprinting method for CGP and conducted a comprehensive methodological investigation. We assessed the similarity among 10 batches of CGP, identified comm...

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