This study was supported by grants from the National Natural Science Foundation of China (No. 81973958, No. 81590950, No. 81774400, No. 81603708), China Postdoctoral Science Foundation (No. 2017M610593, No. 2018T110954, No. 20190037), major program of Sichuan Provincial Education Department (No. 17ZA0157), training program for excellent young innovators of Changsha (No. 201961), open fund project of first-rate discipline of Traditional Chinese Medicine (No. 2018ZYX04), Natural science foundation of Hunan province(No. 2018JJ2303).