Bioeffects of micron-size magnesium particles on inflammatory cells and bone turnover in vivo and in vitro

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成果类型：

期刊论文

作者：

Guo, Chengzhi;Li, Jian;She, Chang;Shao, Xiangzhi;Teng, Bin;...

通讯作者：

Ren, Pei-Gen;Zhang, Jian V.

作者机构：

[She, Chang; Ren, Pei-Gen; Guo, Chengzhi; Shao, Xiangzhi; Li, Jian; Teng, Bin] Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, Shenzhen 518055, Guangdong, Peoples R China.

[She, Chang] Soochow Univ, Dept Orthoped, Affiliated Hosp 2, Suzhou 215000, Jiangsu, Peoples R China.

[Shao, Xiangzhi] Hunan Univ Chinese Med, Changsha 410000, Hunan, Peoples R China.

[Feng, Jing] Wuhan 1 Hosp, Dept Orthoped, Wuhan 430022, Hubei, Peoples R China.

[Zhang, Jian V.] Chinese Acad Sci, Shenzhen Inst Adv Technol, Lab Reprod Hlth, Shenzhen 518055, Guangdong, Peoples R China.

通讯机构：

[Ren, Pei-Gen; Zhang, Jian V.] C

Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, Shenzhen 518055, Guangdong, Peoples R China.

Chinese Acad Sci, Shenzhen Inst Adv Technol, Lab Reprod Hlth, Shenzhen 518055, Guangdong, Peoples R China.

语种：

英文

关键词：

magnesium;bone remodeling;corrosion;particles;inflammation

期刊：

Journal of Biomedical Materials Research - Part B Applied Biomaterials

ISSN：

1552-4973

年：

2016

卷：

104

期：

页码：

923-931

DOI：

10.1002/jbm.b.33411

基金类别：

Pre-973 project, China [2012CB526708]; Shenzhen Peacock Program, China [110811003586331]; Shenzhen basic research program [JCYJ20120615130350920, GJHZ20130417171414743]

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摘要：

Magnesium (Mg) is a promising biodegradable metal offering many potential advantages over current scaffold technologies. Many studies have reported on the corrosion characteristics the Mg and its bioeffects in vitro and in vivo, but there are few studies on the biological effects of the corrosive products of Mg - the micron-size Mg particles (MgMPs). In this study, the effects of size-selected commercial MgMPs on bone turnover and macrophages were investigated in vivo and in vitro. We found that MgMPs were susceptible to engulfment by macrophages, leading to cell lysis, likely resulting from H...

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Bioeffects of micron-size magnesium particles on inflammatory cells and bone turnover in vivo and in vitro

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