Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium

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成果类型：

期刊论文

作者：

Wang, Junfeng;Qin, Li;Zhao, Biqing;Cai, Liang;Zhong, Zhenping;...

通讯作者：

Zhou, Xiaojiang

作者机构：

[Wang, Junfeng; Zhao, Biqing; Zhou, Xiaojiang; Qin, Li] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China.

[Wang, Junfeng; Liu, Yonghong] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China.

[Cai, Liang] Hunan Prov Ctr Dis Control & Prevent, Changsha 410005, Hunan, Peoples R China.

[Zhong, Zhenping] Yao Sheng Tang Hu Nan Pharmaceut Co Ltd, Anxiang 415600, Peoples R China.

通讯机构：

[Zhou, Xiaojiang] H

Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China.

语种：

英文

期刊：

Organic & Biomolecular Chemistry

ISSN：

1477-0520

年：

2019

卷：

期：

页码：

195-202

DOI：

10.1039/c8ob02519c

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31670362]; Hunan Provincial Key Research and Development Program, China [2017NK2261]; Hunan Provincial special projects for tackling key scientific and technological achievements, China [2018GK4027]; National standardization construction project of traditional Chinese Medicine, China [ZYBZH-Y-HUN-24]

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

Crotonols A and B (1 and 2), two tigliane diterpenoids featuring a rare C-7/C-14 cyclized and novel 5/7/7-fused carbon skeleton, along with the known tigliane wallichiioid A, were isolated from the leaves of Croton tiglium. Their structures were determined through spectroscopic methods, X-ray crystallography and ECD analysis. To the best of our knowledge, crotonol B (2) represents the first example of 13,14-seco-tigliane diterpenoids. Crotonols A and B displayed strong cytotoxic activities against the K562 cell line with IC50 values of 0.20 and...

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Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium

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