期刊论文

中文

中华创伤骨科杂志

1671-7600

2010

12

7

668-672

10.3760/cma.j.issn.1671-7600.2010.07.017

湖南省自然科学基金（07JJ6048）~~；

本校为第一机构

目的 观察椎板切除术后用川芎嗪的同时在椎板缺损处植入自体骨膜预防硬膜外粘连的效果.方法 48只SD大鼠随机分成4组(n=12),均制作L2椎板损伤模型, A组硬膜外涂布生理盐水, B组硬膜外涂布川芎嗪, C组硬膜外覆盖自体骨膜, D组硬膜外涂布川芎嗪的同时加自体骨膜覆盖.术后12周对4组椎板切除部位进行大体观察,对粘连度、胶原含量、组织学评分及骨转化生长因子定量分析进行比较.结果 B、C、D组的改良RydellBalazs粘连韧度评分、胶原含量、改良Nussvuaum组织学评分均优于A组,差异有统计学意义(P

Objective To study the effect of Tetramethylpyrazine plus autogenous periosteum on prevention of fibrous scar formation in the epidural space after laminectomy. Methods Forty-eight SD rats were divided randomly into 4 groups.Laminectomy was performed in the segment of lumbar 2.The exposed dura was covered with saline solution (group A),Tetramethyipyrazine(group B),autogenous periostoum(group C)and Tetramethylpyrazine plus autogenous periosteum(group D)respectively.12 weeks postoperatively,evaluation wag based on the gross and histopathological ...