期刊论文

中文

中国中医药信息杂志

1005-5304

2011

18

12

44-47

10.3969/j.issn.1005-5304.2011.12.017

湖南省自然科学基金（10JJ6047）；

本校为第一机构

目的观察滋阴活血解毒方对局灶性脑缺血模型大鼠脑组织凝血酶原mRNA和蛋白酶激活受体(PAR-1)mRNA表达的影响,探讨其脑保护机制。方法将24只大鼠随机分为假手术组、模型组、滋阴活血解毒方组、阿加曲班组,每组分1、3d两个时间点。滋阴活血解毒方组灌服中药水煎剂,每日剂量32.4g/kg；阿加曲班组为腹腔注射给药,第1、2日每日剂量为11.16mg/kg,第3日剂量为3.72mg/kg。假手术组和模型组均灌服等容量生理盐水,每日剂量为2mL/100g。均分2次给药。线栓法制备大脑中动脉闭塞模型。采用反转录-聚合酶链反应(RT-PCR)检测脑组织中凝血酶原mRNA及PAR-1mRNA表达水平。结果与假手术组比较,模型组脑组织中凝血酶...

Objective To observe the effect of Ziyin Huoxue Jiedu decoction on the expression of prothrombim mRNA and protease-activated receptor-1 （PAR-1） mRNA of focal cerebral infarction rats. Methods Twenty-four rats were randomly divided into 4 groups： the sham-operated group, ischemic group, Ziyin Huoxue Jiedu decoction group, Argatroban group. Each group was divided into two time phase point of 1, 3 d. Ziyin Huoxue Jiedu decoction group was fed with Chinese medicine decoction with the daily dose of 32.4 g/kg. Argatroban group was given the intrap...