The Circadian System Is Essential for the Crosstalk of VEGF-Notch-mediated Endothelial Angiogenesis in Ischemic Stroke

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成果类型：

期刊论文

作者：

Zhang, Yuxing;Zhao, Xin;Guo, Chun;Zhang, Ying;Zeng, Fukang;...

通讯作者：

Desheng Zhou<&wdkj&>Lijuan Liu

作者机构：

[Zeng, Fukang; Liu, Lijuan; Guo, Chun; Zhou, Desheng; Li, Zhong; Zhang, Ying; Zhang, Yuxing] Hunan Univ Chinese Med, Hosp 1, Dept Neurol, Changsha 410007, Peoples R China.

[Zeng, Fukang; Zhang, Yuxing] Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha 410208, Peoples R China.

[Shao, Le; Zeng, Fukang; Yin, Qian; Zhao, Xin; Zhang, Ying; Zhang, Yuxing] Hunan Univ Chinese Med, Changsha 410006, Peoples R China.

[Shao, Le] Lab Prevent & Transformat Major Dis Internal Med T, Changsha 410007, Peoples R China.

通讯机构：

[Desheng Zhou; Lijuan Liu] D

Department of Neurology, The First Hospital of Hunan University of Chinese Medicine, Changsha, China<&wdkj&>Department of Neurology, The First Hospital of Hunan University of Chinese Medicine, Changsha, China

语种：

英文

关键词：

Circadian clock;Ischemic stroke;Angiogenesis;VEGF;Notch pathway

期刊：

神经科学通报

ISSN：

1673-7067

年：

2023

卷：

期：

页码：

1375-1395

DOI：

10.1007/s12264-023-01042-9

基金类别：

National Natural Science Foundation for Young Scholars of China [82004346, 82104766]; Natural Science Foundation of Hunan Province [2021JJ30521, 2021JJ40424]; Open Fund for the First-class Discipline of Integrated Traditional Chinese and Western Medicine of Hunan University of Chinese Medicine [2020ZXYJH38, 2020ZXYJH39]; Natural Science Foundation of Changsha [kq2208202]; University-level Fund Project of Hunan University of Chinese Medicine [2021XJJJ039]

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

摘要：

Ischemic stroke is a major public health problem worldwide. Although the circadian clock is involved in the process of ischemic stroke, the exact mechanism of the circadian clock in regulating angiogenesis after cerebral infarction remains unclear. In the present study, we determined that environmental circadian disruption (ECD) increased the stroke severity and impaired angiogenesis in the rat middle cerebral artery occlusion model, by measuring the infarct volume, neurological tests, and angiogenesis-related protein. We further report that Bmal1 plays an irreplaceable role in angiogenesis. O...

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The Circadian System Is Essential for the Crosstalk of VEGF-Notch-mediated Endothelial Angiogenesis in Ischemic Stroke

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