期刊论文

Chen, Jian-xiong

英文

Scientific Reports

2045-2322

2016

6

1

20931

10.1038/srep20931

NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [HL102042]; NATIONAL HEART, LUNG, AND BLOOD INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [R01HL102042, R01HL102042, R01HL102042, R01HL102042, R01HL102042, R01HL102042, R01HL102042] Funding Source: NIH RePORTER

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Recent studies reveal a crucial role of pericyte loss in sepsis-associated microvascular dysfunction. Sirtuin 3 (SIRT3) mediates histone protein post-translational modification related to aging and ischemic disease. This study investigated the involvement of SIRT3 in LPS-induced pericyte loss and microvascular dysfunction. Mice were exposed to LPS, expression of Sirt3, HIF-2α, Notch3 and angiopoietins/Tie-2, pericyte/endothelial (EC) coverage and vascular permeability were assessed. Mice treated with LPS significantly reduced the expression of...