Research on the effects of different sugar substitutes—Mogroside V, Stevioside, Sucralose, and Erythritol—On glucose, lipid, and protein metabolism in type 2 diabetic mice

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成果类型：

期刊论文

作者：

Huang, Huaxue;Wang, Bin;Peng, Zhi;Liu, Sha;Zhan, Shuang;...

通讯作者：

Zhu, YZ;Xiao, WJ

作者机构：

[Zhu, Yizhun; Wang, Wei; Huang, Huaxue] Macau Univ Sci & Technol, Sch Pharm, Taipa 999078, Macao, Peoples R China.

[Huang, Huaxue; Xiao, Wenjun; Xiao, WJ; Liu, Sha; Wang, Bin] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingre, Changsha 410128, Hunan, Peoples R China.

[Yang, Xiulian; Huang, Huaxue; Peng, Zhi; Zhan, Shuang; Huang, Sirui] Hunan Huacheng Biotech Inc, Changsha 410000, Hunan, Peoples R China.

[Wang, Wei; Huang, Huaxue] Hunan Univ Tradit Chinese Med, Sch Pharm, Changsha 410000, Hunan, Peoples R China.

[Yang, Xiulian; Huang, Huaxue; Peng, Zhi; Zhan, Shuang; Huang, Sirui] Hunan Nat Sweetener Engn Technol Res Ctr, Changsha 410000, Hunan, Peoples R China.

通讯机构：

[Zhu, YZ ] M

[Xiao, WJ ] H

Macau Univ Sci & Technol, Sch Pharm, Taipa 999078, Macao, Peoples R China.

Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingre, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Erythritol;Glucose;Lipid and protein metabolism;Mogroside V;Stevioside;Sucralose;Sugar substitute;T2DM

期刊：

Food Research International

ISSN：

0963-9969

年：

2025

卷：

209

页码：

116262

DOI：

10.1016/j.foodres.2025.116262

基金类别：

sources This work was supported by Scientific and Technological Innovation Leading Plan of High-tech Industry in Hunan Province (grant no. 2021GK4018 ). CRediT authorship contribution statement Huaxue Huang: Writing – original draft, Investigation, acquisition, Data curation. Bin Wang: Investigation, Data curation. Zhi Peng: Investigation. Sha Liu: Investigation. Shuang Zhan: Investigation. Xiulian Yang: Data curation. Sirui Huang: Supervision, Conceptualization. Wei Wang: Supervision, Project administration. Yizhun Zhu: Supervision, Resources, Conceptualization. Wenjun Xiao: Writing – review & editing, Project administration, Conceptualization.

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院系归属：

药学院

摘要：

Sugar substitutes that maintain the homeostasis of glucose, lipid, and protein metabolism are important for nutritional intervention in type 2 diabetes mellitus (T2DM). However, the specific metabolic effects remain unclear. The aim of this study was to systematically compare the effects of four common sugar substitutes on a high-fat diet (HFD) combined with a streptozotocin (STZ)-induced T2DM mouse model from the perspective of hepatic glucose, lipid, and protein metabolism. In this study, based on the establishment of a T2DM mouse model induced by an HFD combined with STZ and nontargeted met...

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Research on the effects of different sugar substitutes—Mogroside V, Stevioside, Sucralose, and Erythritol—On glucose, lipid, and protein metabolism in type 2 diabetic mice

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