Effect and underlying mechanism of Huangjing Qianshi decoction in pre-diabetes mouse model

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成果类型：

期刊论文

作者：

Cai, Jialuo;Zhu, Yilin;Deng, Guiming;Ouyang, Linqi;Xiao, Wangzhong;...

通讯作者：

Li, XP

作者机构：

[Cai, Jialuo; Li, Xiaoping] Hunan Univ Chinese Med, Hosp 1, Prevent Treatment Dis Ctr, Changsha 410007, Peoples R China.

[Zhu, Yilin] Hunan Univ Tradit Chinese Med, Grad Sch, Changsha 410208, Peoples R China.

[Deng, Guiming] Hunan Univ Chinese Med, Hosp 1, Dept Sci Res, Changsha 410208, Peoples R China.

[Ouyang, Linqi; Xiao, Wangzhong] Hunan Univ Chinese Med, Hosp 1, Dept Pharm, Changsha 410007, Peoples R China.

[Zhou, Fang] Hunan Univ Chinese Med, Hosp 1, Dept Hlth Management, Changsha 410007, Peoples R China.

通讯机构：

[Li, XP ] H

Hunan Univ Chinese Med, Hosp 1, Prevent Treatment Dis Ctr, Changsha 410007, Peoples R China.

语种：

英文

关键词：

Pre-diabetes;Traditional Chinese medicine;Inflammation;Oxidative stress;Gene regulation

期刊：

BMC Complementary Medicine and Therapies

ISSN：

2662-7671

年：

2025

卷：

期：

页码：

1-13

DOI：

10.1186/s12906-025-04893-z

基金类别：

This work was supported by the Project of guiding innovation of clinical medical technology in Hunan province, China (2021SK51408), Project of scientific research program of Hunan Health Committee, China (B202303066210), Natural Science Foundation of Hunan Province, China (2023JJ60486 and 2021JJ80068), and Scientific research project of traditional Chinese medicine in Hunan province, China (D2022091).

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

药学院

研究生院

摘要：

Insulin secretion deficiency and increased insulin resistance are key pathological pathways that lead to pre-diabetes. Without intervention, pre-diabetes can easily develop into type 2 diabetes mellitus. However, no specific medicine is available for treating pre-diabetes except for intervention through lifestyle changes. Huangjing Qianshi decoction (HJQST) is a qi-replenishing and yin-nourishing Chinese medicinal compound. However, the mode and mechanism of action of HJQST in improving pre-diabetes remain unclear. Here, we studied the effect o...

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Effect and underlying mechanism of Huangjing Qianshi decoction in pre-diabetes mouse model

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