会议论文

Prevention of peridural fibrosis and adhesion after laminectomy by the use of Tetramethylpyrazine and autogenous periosteum

中文

2014

78-83

2014中国骨科学学术交流大会暨中国民族卫生协会骨科专家委员组建会议

2014-07-18

北京

中国民族卫生协会

本校为第一机构

目的:观察椎板切除术后用川芎嗪的同时在椎板缺损处植入自体骨膜预防硬膜外粘连的效果. 方法:48只SD大鼠随机分成A、B、C、D四组,制作L2椎板损伤模型.A组硬膜外涂布生理盐水,B组硬膜外涂布川芎嗪,C组硬膜外覆盖自体骨膜,D组硬膜外涂布川芎嗪的同时加自体骨膜覆盖.术后12周对椎板切除部位进行大体观察、组织学观察、生化检查及骨引导因子定量分析. 结果:B、C、D组的改良Rydell-Balazs粘连韧度评分、胶原含量、改良Nussvuaum组织学评分均优于A组,(P＜0.01),D组优于B组与C组(P＜0.05),TGF-β测量值C组与D组高于A组与B组,差异有显著性(P＜0.01). 结论:联合运用川芎嗪和自体骨膜能有效预防硬膜...

　　Objective:To study the effect of Tetramethylpyrazine cooperated with autogenous periosteum in the prevention of fibrous scar formation in the epidural space after laminectormy.Method:48 SD rats were divided randomly into 4 groups.Laminectomy was performed in lumbar 2 segment,and the exposed duras were covered with saline solution (group A),Tetramethylpyrazine(group B),TMP(group C),and Tetramethylpyrazine and TMP(group D)respectively.12 weeks postoperatively, evaluation was based on the gross and histopathological observation、 biochemistry ...