LncRNA FOXD1-AS1 acts as a potential oncogenic biomarker in glioma

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成果类型：

期刊论文

作者：

Gao, Yuan-Feng;Liu, Jun-Yan;Mao, Xiao-Yuan;He, Zheng-Wen;Zhu, Tao;...

通讯作者：

Liu, Zhao-Qian

作者机构：

[Mao, Xiao-Yuan; Zhu, Tao; Yin, Ji-Ye; Zhang, Wei; Wang, Zhi-Bin; Liu, Zhao-Qian; Zhou, Hong-Hao; Gao, Yuan-Feng; Li, Xi] Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China.

[Mao, Xiao-Yuan; Zhu, Tao; Yin, Ji-Ye; Zhang, Wei; Wang, Zhi-Bin; Liu, Zhao-Qian; Zhou, Hong-Hao; Gao, Yuan-Feng; Li, Xi] Cent S Univ, Hunan Key Lab Pharmacogenet, Inst Clin Pharmacol, Changsha, Hunan, Peoples R China.

[Gao, Yuan-Feng] Hunan Univ Chinese Med, Dept Pharm, Hosp 1, Changsha, Hunan, Peoples R China.

[Liu, Jun-Yan] Univ South China, Dept Orthopaed, Affiliated Hosp 1, Hengyang, Peoples R China.

[He, Zheng-Wen] Cent S Univ, Dept Neurosurg, Affiliated Canc Hosp, XiangYa Sch Med, Changsha, Hunan, Peoples R China.

通讯机构：

[Liu, Zhao-Qian] C

Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

eIF5a;glioma;lncRNA FOXD1-AS1;lncRNAs;miR-339/342

期刊：

CNS Neuroscience & Therapeutics

ISSN：

1755-5930

年：

2020

卷：

期：

页码：

66-75

DOI：

10.1111/cns.13152

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81573463, 81573508 and 81803641]; Open Foundation of Innovative Platform in Colleges and University of Hunan Province [[2015]54]; National Key Research and Development Programs [2016YFC1306900, 2016YFC0905002]; The Strategy-Oriented Special Project of Central South University in China; Clinical Research Fund of Peking University Unamed-Central South University Xiangya Hospital [xywm2015I16, ZLXD2017003]

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

药学院

摘要：

AIMS: Altered activities of long noncoding RNAs (lncRNAs) have been associated with cancer development, and lncRNA FOXD1-AS1 (FOXD1-AS1) is the antisense transcript of the gene encoding for FOXD1, known for its role as an oncogene in several tumor types including glioma. However, the role of FOXD1-AS1 in the differentiation and progression of glioma is not well known. METHODS: Expression profile chip and qPCR were used to screen and identify FOXD1-AS1. Glioma cells were transfected with siRNA or eukaryotic expression vector to observe FOXD1-AS1 function in vitro and in vivo. Dual luciferase re...

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LncRNA FOXD1-AS1 acts as a potential oncogenic biomarker in glioma

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