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LNCRNA FOXD1-AS1 ACTS AS A POTENTIAL ONCOGENIC BIOMARKER IN GLIOMA

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成果类型:
期刊论文
作者:
Gao, Yuan-Feng;Liu, Jun-Yan;Mao, Xiao-Yuan;He, Zheng-Wen;Zhu, Tao;...
通讯作者:
Liu, ZQ
作者机构:
[Mao, Xiao-Yuan; Zhu, Tao; Yin, Ji-Ye; Zhang, Wei; Liu, Zhao-Qian; Wang, Zhi-Bin; Zhou, Hong-Hao; Gao, Yuan-Feng; Li, Xi] Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China.
[Mao, Xiao-Yuan; Zhu, Tao; Yin, Ji-Ye; Zhang, Wei; Wang, Zhi-Bin; Liu, Zhao-Qian; Zhou, Hong-Hao; Gao, Yuan-Feng; Li, Xi] Cent S Univ, Hunan Key Lab Pharmacogenet, Inst Clin Pharmacol, Changsha, Hunan, Peoples R China.
[Gao, Yuan-Feng] Hunan Univ Chinese Med, Dept Pharm, Hosp 1, Changsha, Hunan, Peoples R China.
[Liu, Jun-Yan] Univ South China, Dept Orthopaed, Affiliated Hosp 1, Hengyang, Peoples R China.
[He, Zheng-Wen] Cent S Univ, Dept Neurosurg, Affiliated Canc Hosp, XiangYa Sch Med, Changsha, Hunan, Peoples R China.
通讯机构:
[Liu, ZQ ] C
Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China.
语种:
英文
关键词:
eIF5a;glioma;lncRNA FOXD1-AS1;lncRNAs;miR-339/342
期刊:
CNS Neuroscience & Therapeutics
ISSN:
1755-5930
年:
2020
卷:
26
期:
1
页码:
66-75
基金类别:
Funding information This study was supported by the National Key Research and Development Programs (2016YFC1306900, 2016YFC0905002), National Natural Science Foundation of China (81573463, 81573508 and 81803641), Open Foundation of Innovative Platform in Colleges and University of Hunan Province ([2015]54), Clinical Research Fund of Peking University Unamed-Central South University Xiangya Hospital (xywm2015I16), and The Strategy-Oriented Special Project of Central South University in China (ZLXD2017003).
机构署名:
本校为其他机构
院系归属:
第一中医临床学院
药学院
摘要:
AIMS: Altered activities of long noncoding RNAs (lncRNAs) have been associated with cancer development, and lncRNA FOXD1-AS1 (FOXD1-AS1) is the antisense transcript of the gene encoding for FOXD1, known for its role as an oncogene in several tumor types including glioma. However, the role of FOXD1-AS1 in the differentiation and progression of glioma is not well known. METHODS: Expression profile chip and qPCR were used to screen and identify FOXD1-AS1. Glioma cells were transfected with siRNA or eukaryotic expression vector to observe FOXD1-AS1 function in vitro and in vivo. Dual luciferase re...

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