期刊论文

Tang, FQ

英文

Cell Death & Disease

2041-4889

2023

14

7

459

10.1038/s41419-023-05985-9

This work was supported in part by Major Scientific and Technological Innovation Project of Hunan Province (2021SK1020-4), Natural Science Foundation of Hunan Province (2018JJ6131, 2019JJ40175, and 2021JJ70098), Changsha Science and Technology Project (kg1801107 and kq2004136), and Research Projects of Hunan Health Commission (B2019084).

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Oncogenic super-enhancers (SEs) generate noncoding enhancer/SE RNAs (eRNAs/seRNAs) that exert a critical function in malignancy through powerful regulation of target gene expression. Herein, we show that a JUN-mediated seRNA can form R-loop to regulate target genes to promote metastasis of nasopharyngeal carcinoma (NPC). A combination of global run-on sequencing, chromatin-immunoprecipitation sequencing, and RNA sequencing was used to screen seRNAs. A specific seRNA associated with NPC metastasis (seRNA-NPCM) was identified as a transcriptional regulator for N-myc downstream-regulated gene 1 (...