The underlying rationality of Chinese medicine herb pair Coptis chinensis and Dolomiaea souliei: From the perspective of metabolomics and intestinal function

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成果类型：

期刊论文

作者：

Wang, Ting;Zhang, Chongyang;Li, Hui;Zhou, Rui;Ye, Xiaoli;...

通讯作者：

Xiaoli Ye<&wdkj&>Kai He

作者机构：

[Zhou, Rui; Wang, Ting; Zhang, Chongyang; He, Kai; Li, Hui] Hunan Univ Med, Sch Pharmaceut Sci, Hunan Prov Key Lab Dong Med, Hunan Prov Key Lab Synthet Biol Tradit Chinese Me, Huaihua 418000, Hunan, Peoples R China.

[Ye, Xiaoli] Southwest Univ, Sch Life Sci, Engn Res Ctr Coptis Dev & Utilizat, Minist Educ, Chongqing 400715, Peoples R China.

[Yang, Yong] Hunan Univ Tradit Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Xiaoli Ye] E

[Kai He] H

Hunan Provincial Key Laboratory of Dong Medicine, Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, School of Pharmaceutical Science, Hunan University of Medicine, Huaihua, 418000, Hunan, China<&wdkj&>Engineering Research Center of Coptis Development and Utilization (Ministry of Education), School of Life Sciences, Southwest University, Chongqing, 400715, China

语种：

英文

关键词：

Coptis chinensis;Dolomiaea souliei;Intestinal function;Metabolomics;Xiang-lian-Wan

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2022

卷：

289

页码：

115065

DOI：

10.1016/j.jep.2022.115065

基金类别：

CRediT authorship contribution statement Ting Wang: Methodology, Investigation. Chongyang Zhang: Methodology, Investigation. Hui Li: Data curation, Software, Visualization. Rui Zhou: Data curation, Software, Visualization. Xiaoli Ye: Supervision, acquisition, and Reviewing. Yong Yang: Data curation, Software, Visualization. Kai He: Conceptualization, Methodology, Writing, acquisition.

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

ETHNOPHARMACOLOGICAL RELEVANCE: The combination of Coptis chinensis (RC) and Dolomiaea souliei (VR) has long been used as a classic herb pair for the treatment of gastrointestinal diseases, but the underlying mechanisms remain unknown. MATERIALS AND METHODS: In this study, the rationality of evidence-based RC and VR combination was explored from the perspective of metabolism, gut microbiota and gastrointestinal function. RESULTS: After 5 weeks treatment, VR extracts (700mg/kg) and RC alkaloids (800mg/kg) showed no toxic effect on mice. However, RC administration significantly decreased the bod...

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The underlying rationality of Chinese medicine herb pair Coptis chinensis and Dolomiaea souliei: From the perspective of metabolomics and intestinal function

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