期刊论文

Effects of Stasis-resolving and Detoxificating Method on Expression of Thrombin and its Receptor,Monocyte Chemoattractant Protein（ MCP-1）,Nuclear Factor κB（ NF-κB）,and Infiltration of Neutrophil in MCAO Rats

中文

世界中医药

1673-7202

2016

11

4

575-579

10.3969/j.issn.1673-7202.2016.04.003

14JJ2113:湖南省自然科学基金 201319:湖南省中医药科研项目 201606:湖南省中医药科研项目 12A105:湖南省教育厅项目

本校为第一机构

目的:观察化瘀解毒法对MCAO大鼠凝血酶及其受体、大鼠脑组织中单核细胞趋化蛋白(MCP-1)、核因子κB(NF-κB)的表达及中性粒细胞浸润的影响,探讨凝血酶与炎性因子之间的关联性及化瘀解毒法的干预作用.方法:MCAO大鼠分手术组、模型组、活血化瘀法组、清热解毒法组、化瘀解毒法组、阿加曲班组、PDTC组等7组,分组给药,检测各组大鼠给药后脑组织凝血酶及其受体、MCP-1和NF-κB的mRNA表达和蛋白表达水平,并观察缺血区脑组织中性粒细胞浸润情况.结果:模型组脑组织凝血酶及其受体、MCP-1、NF-κB的mRNA表达和蛋白表达均增强(P＜0.05),各治疗组治疗后上述指标均下降(P＜0.05),化瘀解毒法组较明显;各组大鼠...

Objective： To observe the effects of stasis-resolving and detoxificating method on the expression of thrombin and its receptor（ PAR-1）,monocyte chemoattractant protein（ MCP-1）,nuclear factor κB（ NF-κB） and infiltration of neutrophil in brain tissue of MCAO rats,and to discuss the association between thrombin and inflammatory factors and the intervention effects of stasis-resolving and detoxificating method. Methods： The MCAO rats were randomly divided into 7 groups： the sham-operated group,the model group,the blood-activating and sta...