Construction and verification of a novel circadian clock related long non-coding RNA model and prediction of treatment for survival prognosis in patients with hepatocellular carcinoma
This work was supported by National Natural Science Foundation of China (82074425); Natural Science Foundation of Hunan Province (2021JJ30417); Key R&D projects in Hunan Province (2021SK2006); Top Technology Leading Talents Project of Hunan Province (2022RC3081); Research project of Health Commission of Hunan Province (202203105606, 202113051181).
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本校为第一机构
摘要：
Circadian clock genes are significant in the occurrence and development of HCC and long-non coding RNAs (lncRNAs) are closely related to HCC progression. In this study, we aimed to establish a prognostic risk model for HCC. Circadian clock-related lncRNAs expressed in HCC were extracted from The Cancer Genome Atlas. A nomogram was established to predict individual survival rate. Biological processes enriched for risk model transcripts were investigated by Gene Set Enrichment Analysis. Further, we evaluated the relationship between risk score and immune-checkpoint inhibitor-related gene express...
