Ginsenoside (Rg-1) promoted the wound closure of diabetic foot ulcer through iNOS elevation via miR-23a/IRF-1 axis

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成果类型：

期刊论文

作者：

Cai, Hua-An;Huang, Liang;Zheng, Li-Jun;Fu, Kun;Wang, Jing;...

通讯作者：

Liao, Ruo-Yi

作者机构：

[Cai, Hua-An; Huang, Liang; Zheng, Li-Jun; Fu, Kun; Wang, Jing] Hunan Normal Univ, Affiliated Hosp 1, Hunan Prov Peoples Hosp, Dept Physiatr, Changsha 410016, Hunan, Peoples R China.

[Hu, Feng-Dan] Hunan Normal Univ, Affiliated Hosp 1, Hunan Prov Peoples Hosp, Changsha 410005, Hunan, Peoples R China.

[Liao, Ruo-Yi] Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, 95,Lushan Middle Rd, Changsha 410007, Hunan, Peoples R China.

通讯机构：

[Liao, Ruo-Yi] H

Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, 95,Lushan Middle Rd, Changsha 410007, Hunan, Peoples R China.

语种：

英文

关键词：

DFUs;Ginsenoside;IRF-1;Wound healing;iNOS;miR-23a

期刊：

Life Sciences

ISSN：

0024-3205

年：

2019

卷：

233

页码：

116525

DOI：

10.1016/j.lfs.2019.05.081

基金类别：

Authors' contributions Ruo-Yi Liao and Hua-An Cai conceived and designed the experiments, acquisition; Liang Huang performed the experiments; Li-Jun Zheng, Kun Fu and Jing Wang contributed reagents/materials/analysis tools; Feng-Dan Hu wrote the paper. All authors read and approved the final manuscript.

机构署名：

本校为通讯机构

院系归属：

第一中医临床学院

摘要：

BACKGROUND: Impaired wound healing in diabetes foot ulcers (DFUs) brings a great burden to diabetic patients. Pro-angiogenesis through elevating nitric oxide (NO) is beneficial to the wound healing process. Ginsenoside Rg1, the main active in Notoginseng, is reported to regulate the angiogenesis in endothelial cells through modulating miR-23a. However, the effect of Rg1 in diabetes remains elusive. METHODS: High fat diet combined with streptozotocin-induced diabetic rats were treated with Rg1. Then incision area and tissue NO level were measured to evaluate the wound closure efficacy of Rg1. T...

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Ginsenoside (Rg-1) promoted the wound closure of diabetic foot ulcer through iNOS elevation via miR-23a/IRF-1 axis

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