Objective: The high mortality rate associated with acute respiratory distress syndrome (ARDS) is a major challenge for intensive care units. In the present study, we applied bioinformatics and animal models to identify core genes and potential corresponding pathways in ARDS. Results: Using bioinformatics analysis, IL-1 beta was identified as the core gene of ARDS. Cell experiments showed that up-regulation of IL-1 beta downregulates claudin18 to promote lung barrier function damage by regulating the IL-1 beta-HER2/HER3 axis, further promoting the development of ARDS. This was validated in the ...
