This research was financially supported by the Natural Science Foundation of Hunan Province (No. 2022JJ40332) and the Domestic First-class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine (4901-020000200207).
机构署名：
本校为第一且通讯机构
院系归属：
第一中医临床学院
摘要：
Intestinal microbiota disorder was associated with constipation. This study investigated the microbiota-gut-brain axis and oxidative stress mediated by intestinal mucosal microbiota in mice with spleen deficiency constipation. The Kunming mice were randomly divided into the control (MC) group and the constipation (MM) group. The spleen deficiency constipation model was established by gavage with Folium sennae decoction and controlled diet and water intake. The body weight, spleen and thymus index, 5-Hydroxytryptamine (5-HT) and Superoxide Dismutase (SOD) content were significantly lower in the...
