期刊论文

Effects of Qingre Jiedu Huazhuo tablets on ADP, TNF-α and IL-10 in rat model of fatty liver disease

中文

中国肝脏病杂志(电子版)

1674-7380

2016

8

1

67-71

10.3969/j.issn.1674-7380.2016.01.013

湖南省教育厅重点项目（12A101）；

本校为第一机构

目的研究清热解毒化浊片对脂肪性肝病大鼠脂肪因子ADP及炎性因予TNF-α、IL-10的影响。方法采用高脂饮食、酒精灌胃建立脂肪性肝病大鼠模型。造模成功后,随机分为清热解毒化浊片组、非诺贝特组、模型组和正常组4组,每组10只,清热解毒化浊片组按0.081 g/ml灌胃,非诺贝特组按0.083 g/ml灌胃,模型组及正常组予等体积蒸馏水灌胃,每组动物灌胃量均为1 ml/（100 g·d）。经治疗30天后观察肝组织病理学改变,采用全自动生化仪检测血清甘油三酯（TG）、总胆固醇（TC）、丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）活性,ELISA法检测血清脂联素（ADP）、白细胞介素10（IL-10）、肿瘤坏死因子α（...

Objective To investigate the effects of Qingre Jiedu Huazhuo tablets on ADP, TNF-αand IL-10 in rat model of fatty liver disease. Methods The rat liver inlfammation model was established by feeding high sugar, fat and liquor. The rats were randomly divided into normal group, model group, Fenoifbrate group and Qingre Jiedu Huazhuo group, 10 rats in each group. Qingre Jiedu Huazhuo tablets (0.081 g/ml) and Fenoifbrate (0.083 g/ml) were used to treat liver inflammatory model rat for 30 days [1 ml/(100g·d)], respectively. The content of blood seru...