Astragaloside IV ameliorates pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension by restraining the T follicular helper cell response and expanding T follicular regulatory cell response

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成果类型：

期刊论文

作者：

Li, Cheng;Zhu, Hao;Zhang, Shaoze;Meng, Fang;Li, San;...

作者机构：

[Zhang, Shaoze; Li, Cheng; Li, Guang; Zhu, Liming; Dai, Aiguo; Meng, Fang; Li, San; Zhu, Hao] Hunan Normal Univ, Affiliated Hosp 1, Hunan Prov Peoples Hosp, Dept Resp & Crit Care Med, Changsha 410016, Hunan, Peoples R China.

[Dai, Aiguo; Zha, Jun] Hunan Univ Chinese Med, Med Sch, Dept Resp Dis, Changsha 410208, Hunan, Peoples R China.

[Wu, Shangjie] Cent South Univ, Xiangya Hosp 2, Dept Resp & Crit Care Med, Changsha 410011, Hunan, Peoples R China.

语种：

英文

关键词：

ASIV;Astragaloside IV;HPH;hypoxia-induced pulmonary hypertension;PASMCs;pulmonary artery smooth muscle cells;Tfh;T follicular helper cell;Tfr;T follicular regulatory cell;mPAP;mean pulmonary artery pressure;PAMT;pulmonary arteriole media thickness;α-SMA;α-smooth muscle actin;GC;germinal center;mTOR;mechanistic target of rapamycin;BCL-6;B-cell lymphoma 6 protein;CTLA4;cytotoxic T-lymphocyte-associated protein 4

期刊：

Phytomedicine

ISSN：

0944-7113

年：

2022

卷：

102

页码：

154171

DOI：

10.1016/j.phymed.2022.154171

基金类别：

National Natural Science Foundation of China [81900056]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

BACKGROUND: Pulmonary hypertension (PH) is a progressive disorder lacking a validated and effective therapy which characterized by elevated pulmonary arterial pressure, vascular remodeling and eventual death. FDA approved sildenafil is being used as a first-line drug for PH, however, neither survival rates nor quality of life have been improved because of side effects and patient noncompliance. Thus, the exploration of novel therapeutic drugs is urgently needed. Astragaloside IV (ASIV) exhibits a protective effect on HPH, but its mechanisms of ...

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Astragaloside IV ameliorates pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension by restraining the T follicular helper cell response and expanding T follicular regulatory cell response

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