Astragaloside IV ameliorates peritoneal fibrosis by promoting PGC‐1α to reduce apoptosis in vitro and in vivo

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成果类型：

期刊论文

作者：

Xie, Mingxia;Xia, Bohou;Xiao, Lan;Yang, Dun;Li, Zhenghong;...

通讯作者：

Zhang, Xi;Peng, QH

作者机构：

[Yang, Dun; Peng, Qinghua; Xiao, Lan; Xie, Mingxia; Xia, Bohou; Wang, Xiaoye; Zhang, Xi; Zhang, X] Hunan Univ Chinese Med, Coll Clin Med, Changsha 410007, Hunan, Peoples R China.

[Peng, Qinghua; Xie, Mingxia] Hunan Univ Chinese Med, Coll Tradit Chinese Med, Changsha, Peoples R China.

[Yang, Dun; Xiao, Lan; Wang, Hanqing; Xia, Bohou] Hunan Univ Chinese Med, Coll Pharm, Changsha, Peoples R China.

[Li, Zhenghong] Nanjing Univ Chinese Med, Affiliated Hosp, Jiangsu Prov Hosp Chinese Med, Dept Nephrol, Nanjing, Peoples R China.

[Wang, Hanqing] Ningxia Med Univ, Coll Pharm, Yinchuan, Peoples R China.

通讯机构：

[Peng, QH ; Zhang, X] H

Hunan Univ Chinese Med, Coll Clin Med, Changsha 410007, Hunan, Peoples R China.

语种：

英文

关键词：

Astragaloside IV;PGC-1α;apoptosis;mitochondria;peritoneal fibrosis

期刊：

Journal of Cellular and Molecular Medicine

ISSN：

1582-1838

年：

2023

卷：

期：

页码：

2945-2955

DOI：

10.1111/jcmm.17871

基金类别：

Hunan University of Chinese Medicine [22JBZ024]; Key Projects of Hunan Provincial Department of Education [22A0259]; China Postdoctoral Science Foundation [2021M690990]; 2021 "Academician Liu Liang Workstation" Guidance Project [21YS002]; Open Fund Project of State Key Laboratory Cultivation Base Jointly Constructed by Ministry and Province [2022FTKFJJ09]; Hunan Province Clinical Medical Technology Innovation Guidance Project [2021SK50809]; Key Project of the First -Class Subject Open Fund of the Education Department of Hunan Province [2020ZXYJH12]

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

药学院

摘要：

Prolonged exposure of the peritoneum to high glucose dialysate leads to the development of peritoneal fibrosis (PF), and apoptosis of peritoneal mesothelial cells (PMCs) is a major cause of PF. The aim of this study is to investigate whether Astragaloside IV could protect PMCs from apoptosis and alleviate PF. PMCs and rats PF models were induced by high glucose peritoneal fluid. We examined the pathology of rat peritoneal tissue by HE staining, the thickness of rat peritoneal tissue by Masson's staining, the number of mitochondria and oxidative...

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Astragaloside IV ameliorates peritoneal fibrosis by promoting PGC‐1α to reduce apoptosis in vitro and in vivo

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