Activation of hippocampal MEK1 contributes to the cumulative antinociceptive effect of electroacupuncture in neuropathic pain rats

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成果类型：

期刊论文

作者：

Gao, Yong-Hui;Li, Cheng-Wen;Wang, Jun-Ying;Kan, Yu;Tan, Lian-Hong;...

通讯作者：

Liu, Jun-Ling

作者机构：

[Kan, Yu; Liu, Jun-Ling; Gao, Yong-Hui; Tan, Lian-Hong; Wang, Jun-Ying] China Acad Chinese Med Sci, Inst Acupuncture & Moxibust, Dept Physiol, Beijing 100700, Peoples R China.

[Li, Cheng-Wen] Hunan Univ Chinese Med, Coll Acupuncture & Moxibust & Tui Na, Changsha 410208, Hunan, Peoples R China.

[Li, Cheng-Wen] Hunan Tradit Chinese Med Coll, Affiliated Hosp 1, Zhuzhou 412012, Hunan, Peoples R China.

[Jing, Xiang-Hong] China Acad Chinese Med Sci, Inst Acupuncture & Moxibust, Meridian Res Ctr, Beijing, Peoples R China.

通讯机构：

[Liu, Jun-Ling] C

China Acad Chinese Med Sci, Inst Acupuncture & Moxibust, Dept Physiol, Beijing 100700, Peoples R China.

语种：

英文

关键词：

Acupuncture analgesia;Neuropathic pain;Cumulative effect;Hippocampus;Mitogen-activated protein kinase kinase 1

期刊：

BMC Complementary Medicine and Therapies

ISSN：

2662-7671

年：

2016

卷：

期：

页码：

1-11

DOI：

10.1186/s12906-016-1508-z

基金类别：

National Nature Science FoundationNational Natural Science Foundation of China (NSFC) [81473779, 81102647, 81330087, 30973796]; Special Project of Chinese Medicine (973) of the National Basic Research Program of ChinaNational Basic Research Program of China [2013CB531904]

机构署名：

本校为其他机构

院系归属：

针灸推拿与康复学院

摘要：

Background: Electroacupuncture (EA) intervention can relieve a variety of pain; however, optimal EA protocols have not been clearly determined. In addition, although central mitogen-activated protein kinase kinase (MEK) signaling has been shown to be involved in the antinociceptive effect of acupuncture stimulation, its characteristics at different time-points of EA intervention have not been fully elucidated. Therefore, the present study investigated the relationship between the effects of different numbers of EA intervention sessions and the ...

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Activation of hippocampal MEK1 contributes to the cumulative antinociceptive effect of electroacupuncture in neuropathic pain rats

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