Analysis of LAP(+) and GARP(+) Treg subsets in peripheral blood of patients with neuromyelitis optica spectrum disorders

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成果类型：

期刊论文

作者：

Cai, Haobing;Liu, Yu;Dong, Xiaohua;Jiang, Fei;Li, Hongliang;...

通讯作者：

Qiuming Zeng<&wdkj&>Huan Yang

作者机构：

[Zeng, Qiuming; Jiang, Fei; He, Ting; Dong, Xiaohua; Cai, Haobing; Yang, Huan] Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha, Peoples R China.

[Liu, Yu] Second Peoples Hosp Hunan Prov, Brain Hosp Hunan Prov, Changsha, Peoples R China.

[Li, Hongliang] Hunan Univ Chinese Med, Acupuncture & Tuina Rehabil Dept, Hosp 1, Changsha, Peoples R China.

[Ouyang, Song] South China Univ, Hosp Changsha City 1, Med Ctr Neurol, Changsha, Peoples R China.

[Yin, Weifan] Cent South Univ, Xiangya Hosp 2, Changsha, Peoples R China.

通讯机构：

[Qiuming Zeng; Huan Yang] D

Department of Neurology, Xiangya Hospital, Central South University, Changsha, China<&wdkj&>Department of Neurology, Xiangya Hospital, Central South University, Changsha, China

语种：

英文

关键词：

Glycoprotein A repetitions predominant;Latency-associated peptide;Neuromyelitis optica spectrum disorders;Regulatory T cells;Transforming growth factor-β1

期刊：

Neurological Sciences

ISSN：

1590-1874

年：

2023

卷：

期：

页码：

1739-1747

DOI：

10.1007/s10072-023-06629-8

基金类别：

This study was supported by the grants from the National Science Foundation of China (Grant Number: 81801203), the Hunan Academician Expert Workstation (Shi Xuemin) Open-end Fund Project (2019YSZJJ12), the Natural Science Foundation of Hunan Province (Grant Number: 2022JJ40724), the Science and Technology Innovation Guidance Project of Hunan Province (2020SK53009), and the Changsha Municipal Natural Science Foundation (kq2007037).

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

INTRODUCTION: Neuromyelitis optica spectrum disorder (NMOSD) is a group of antibody-mediated inflammatory demyelinating central nervous system diseases. T lymphocytes participate in NMOSD pathogenesis, with regulatory T cells (Treg) being the core in maintaining immune homeostasis. Studies have revealed that different Treg subsets play different roles in autoimmune diseases. The distribution of LAP(+) or GARP(+) Treg subsets in NMOSD may help us deeply understand their immune mechanism. METHODS: This study reviewed 22 NMOSD patients and 20 norm...

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Analysis of LAP(+) and GARP(+) Treg subsets in peripheral blood of patients with neuromyelitis optica spectrum disorders

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