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Helicobacter pylori Infection Impairs Endothelial Function Through an Exosome-Mediated Mechanism

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成果类型:
期刊论文
作者:
Xia, Xiujuan;Zhang, Linfang;Chi, Jingshu;Li, Huan;Liu, Xiaoming;...
通讯作者:
Xu, CX;Liu, ZG
作者机构:
[Liu, Xiaoming; Li, Rong; Zhang, Linfang; Wang, Hui; Li, Huan; Xu, Canxia; Zhang, Xue; Xia, Xiujuan; Guo, Yinjie] Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Tongzipo Rd 138, Changsha 410013, Hunan, Peoples R China.
[Cai, Jin; Chi, Jingshu] Cent South Univ, Dept Cardiol, Xiangya Hosp 3, Changsha, Peoples R China.
[Zhang, Xue; Zheng, Xilong] Univ Calgary, Dept Physiol & Pharmacol, Calgary, AB, Canada.
[Liu, Da; Liao, Duanfang] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Changsha, Peoples R China.
[Liu, Da; Cai, Jin; Zhang, Linfang; Hu, Tingzi; Raker, Gregory C.; Liu, Zhenguo; Hao, Hong; Xia, Xiujuan; Liao, Duanfang; Li, Yixi; Cui, Yuqi] Univ Missouri Sch, Ctr Precis Med, Columbia, MO USA.
通讯机构:
[Xu, CX ] C
[Liu, ZG ] U
Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Tongzipo Rd 138, Changsha 410013, Hunan, Peoples R China.
Univ Missouri, Sch Med, Dept Med, Div Cardiovasc Med,Ctr Precis Med, Columbia, MO 65212 USA.
语种:
英文
关键词:
cardiovascular risk factor;endothelial dysfunction;exosomes;Helicobacter pylori
期刊:
Journal of the American Heart Association
ISSN:
2047-9980
年:
2020
卷:
9
期:
6
页码:
e014120
基金类别:
This work was supported by grants from the National Natural Scientific Foundation of China (No. 81570509), Hunan Natural Science Foundation of China (No. 2018JJ6136), New Xiangya Talent Project of the Third Xiangya Hospital of Central South University (No. 20150310), and US NIH grants HL148196 and ES026200 (Liu).
机构署名:
本校为其他机构
院系归属:
药学院
摘要:
Background Epidemiological studies have suggested an association between Helicobacter pylori ( H pylori ) infection and atherosclerosis through undefined mechanisms. Endothelial dysfunction is critical to the development of atherosclerosis and related cardiovascular diseases. The present study was designed to test the hypothesis that H pylori infection impaires endothelial function through exosome‐mediated mechanisms. Methods and Results Young male and female patients (18‐35 years old) with and without H pylori infectio...

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