Increased cell apoptosis in human lung adenocarcinoma and in vivo tumor growth inhibition by RBM10, a tumor suppressor gene

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成果类型：

期刊论文

作者：

Ji, Yunxi;Xie, Sheng;Jiang, Li;Liu, Lijian;Li, Liumei;...

通讯作者：

Tang, Nong;Liu, Bugu

作者机构：

[Liu, Lijian; Xie, Sheng; Ji, Yunxi] Guangxi Univ Chinese Med, Affiliated Hosp 1, Dept Gastroenterol, Nanning 530000, Guangxi, Peoples R China.

[Liu, Bugu; Tang, Nong; Jiang, Li] Guangxi Univ Chinese Med, Affiliated Hosp 1, Dept Oncol, Nanning 530000, Guangxi, Peoples R China.

[Li, Liumei; Luo, Lichuan; Zhang, Jianxuan; Chen, Yan; Zhang, Yaozhong] Guangxi Univ Chinese Med, Sch Grad Study, Nanning 530000, Guangxi, Peoples R China.

[Yu, Lei] Hunan Univ Chinese Med, Sch Grad Study, Changsha 410000, Hunan, Peoples R China.

[Tang, N; Liu, BG] Guangxi Univ Chinese Med, Dept Oncol, 179 Mingxiu East Rd, Nanning 530000, Guangxi, Peoples R China.

通讯机构：

[Tang, N; Liu, BG] G

Guangxi Univ Chinese Med, Dept Oncol, 179 Mingxiu East Rd, Nanning 530000, Guangxi, Peoples R China.

语种：

英文

关键词：

A549 cells;RNA-binding motif protein 10;lung adenocarcinoma;tumor model

期刊：

Oncology Letters

ISSN：

1792-1074

年：

2017

卷：

期：

页码：

4663-4669

DOI：

10.3892/ol.2017.6765

机构署名：

本校为其他机构

摘要：

Tumor suppressor genes are frequently deleted or mutated in lung cancer. The RNA‑binding motif protein 10 (RBM10) gene has the ability to suppress tumor activity, but the role of RBM10 during the development of lung cancer has yet to be elucidated. The current study investigated the expression levels of RBM10 in non‑tumor and tumor tissues obtained from patients with adenocarcinoma using reverse transcription‑polymerase chain reaction and western blot analysis, and identified a reduction in RBM10 expression in lung tumor tissue. To investiga...

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Increased cell apoptosis in human lung adenocarcinoma and in vivo tumor growth inhibition by RBM10, a tumor suppressor gene

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