会议论文

Study of Stable Regularity of Dissolution for CMM in Processing of Dynamic Extract

中文

2013

1-3

第四届中医药现代化国际科技大会

第四届中医药现代化国际科技大会论文集

2013-09-26

成都

科技部<&wdkj&>中国科学院<&wdkj&>中国工程院<&wdkj&>国家中医药管理局

本校为第一机构

众所周知,中药制剂的质量优劣攸关中医临床疗效与安全,探讨中药制剂质量控制方法与技术是中医药现代化的战略关键问题之一,长期倍受国内外学者高度关注.迄今,横亘于中药制剂生产中的第一道鸿沟是动态中药提取的稳态性难题.缘于中药材多以动植物体入药,具有遗传多态性;中药提取过程受到提取溶媒、提取时间、提取温度、溶媒用量等诸多因素的影响,致使所获得的中药浸膏质量处于动态波动之中,表现在中药提取批间浸膏质量差异大,给中药制剂成型工艺带来困难,难以保证中药成品制剂的质量稳定.因此,欲确保获得优质、稳定;可控而用于临床的中药制剂,则必须对动态的中药提取过程所蕴藏的溶出稳态性规律进...

　　it is well known that Chinese Materia Medica Preparation (CMMP) qualities play an important role in clinical effects and safety in medical practice.It is a key strategic problem to deal with the methods and techniques to control CMM qualities,which attract great attention of researchers at home and aboard for a long time.Up to now,it is a tough problem in CMMP production how to stably control the dissolution of ingredients in processing CMM dynamic extracts.Because CMM mainly come from animals and plants that have genetic polymorphism,dynam...