期刊论文

Zhang, K.

中文

中国医学影像技术

1003-3289

2022

38

10

1446-1451

10.13929/j.issn.1003-3289.2022.10.002

湖南中医药大学“十三五”一级学科（4901-020000200806）； 湖南省科技人才托举工程项目-年轻优秀科技工作者培养计划（2022TJ-N05）；

本校为第一机构

目的 观察3.0T MR T1ρ及T2 mapping评估兔股骨内侧髁关节软骨退变的价值.方法 将40只兔随机分为2周组、4周组、6周组及对照组各10只.对2周组、4周组及6周组兔建立右后肢膝骨关节炎模型并分别制动2、4及6周,对照组不予处理;行T1ρ及T2 mapping成像.处死动物后取股骨内侧髁关节软骨病变最严重区域行病理切片及染色;根据国际骨关节炎研究学会(OARSI)分级标准分为正常组、退变早期组及退变中晚期组,测定Ⅱ型胶原、蛋白多糖、β-Catenin及基质金属蛋白酶(MMP)-13,观察T1ρ及T2 mapping评估其关节软骨退变的价值.结果 最终对37只兔造模成功,正常组8只、早期退变组20只、中晚期退变组9只;3组股骨内侧髁...

Objective To observe the value of 3. OT MR T1p and T2 mapping for evaluating articular cartilage degeneration of medial femoral condyle in rabbits. Methods Forty rabbits were randomly divided into 2-week group, 4-week group, 6-week group and control group (each n = 10). The knee osteoarthritis models of the right hind limb were established in 2-week, 4-week and 6-week group with braking time of 2, 4 and 6 weeks, respectively. Tip and T2 mapping of the right hind knee joint were perlormed. The rabbits were then sacrificed, the most serious areas...