At present,the number of smokers in China is about 350 millionuntry,accounting one third of the global smokers,at the top of the world ranking list.By 2020,the death related to smoking will be increasing to 2 million.What's more,there will be 100 million people are estimated to die of the tobacco-related diseases.Therefore,it makes great sense to use biological technology to improve the tobacco's quality and to reduce the rate of death.This paper summarizes the results from researches at home and abroad in nearly a century,in which scholars u...